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Genome-Wide Analysis of the Metallocarboxypeptidase Inhibitor Family Reveals That Affects Root Development and Tropane Alkaloid Production in .
Int J Mol Sci
December 2024
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, SWU-TAAHC Medicinal Plant Joint R&D Centre, School of Life Sciences, Southwest University, Chongqing 400715, China.
is a medicinal plant and an important source for the commercial production of tropane alkaloids (TAs), such as scopolamine and hyoscyamine, which are used clinically for their anticholinergic properties. In this study, we identified 16 metallocarboxypeptidase inhibitor (MCPI) genes from (), which are grouped into three subgroups based on phylogenetic relationships and are distributed across 10 chromosomes. Promoter analysis showed that most elements were related to defense and stress responses, such as drought, low-temperature, ABA (abscisic acid), GA (gibberellin), auxin, light and MeJA responsiveness.
View Article and Find Full Text PDFThe Induction of Disease Resistance by Scopolamine and the Application of Extract Against Potato ( L.) Late Blight.
Int J Mol Sci
December 2024
School of Life Sciences, Chongqing University, Chongqing 401331, China.
Late blight, caused by , is a devastating disease of potato. Our previous work illustrated that scopolamine, the main bioactive substance of extract, exerts direct inhibitory effects on , but it is unclear whether scopolamine and extract can boost resistance to late blight in potato. In this study, .
View Article and Find Full Text PDFRisk Factors and Postoperative Complications of Lobectomy for Non-Small Cell Lung Cancer: An Exploratory Analysis of Premedication and Clinical Variables.
Medicina (Kaunas)
December 2024
Department of Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52 Ostrava, Czech Republic.
: Postoperative pneumonia and complications significantly impact outcomes in thoracic surgery, particularly for patients undergoing lobectomy for non-small cell lung cancer (NSCLC). This study evaluates whether preoperative premedication influences the risk of postoperative pneumonia and overall complications. : This retrospective study included 346 patients who underwent lobectomy for NSCLC at the University Hospital Ostrava between 2015 and 2021.
View Article and Find Full Text PDFEvaluation of the effectiveness of medroxyprogesterone on blood gases and short-term hospital outcomes in patients with chronic obstructive pulmonary disease treating with noninvasive ventilation: A randomized clinical trial.
J Res Med Sci
November 2024
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: In the present study, we aimed to evaluate the effects of medroxyprogesterone on hospital short clinical outcomes and ABG parameters in patients with chronic obstructive pulmonary disease (COPD) exacerbation under treatments with noninvasive ventilation (NIV) treated with progesterone 15 mg in comparison with placebo.
Materials And Methods: This is a double-blinded clinical trial that was performed in 2020-2021 in Isfahan, Iran, on 60 patients with COPD exacerbation that require NIV. All patients received short-acting beta-agonists, short-acting anticholinergics, systemic corticosteroids, and NIV.
Artemisinin-Quinidine Combination for Suppressing Ventricular Tachyarrhythmia in an Ex Vivo Model of Brugada Syndrome.
J Korean Med Sci
January 2025
Division of Cardiology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Background: The ionic mechanism underlying Brugada syndrome (BrS) arises from an imbalance in transient outward current flow between the epicardium and endocardium. Previous studies report that artemisinin, originally derived from a Chinese herb for antimalarial use, inhibits the Ito current in canines. In a prior study, we showed the antiarrhythmic effects of artemisinin in BrS wedge preparation models.
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