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The epitope of the antibody used in the REAADS VWF activity assay is quaternary.
Thromb J
January 2025
Division of Hematology, Departments of Internal Medicine and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
The REAADS VWF activity assay is often assumed to be specific for the A1 domain, the portion of VWF that binds platelet GPIbα. We tested this assay on the A1A2A3 region of VWF with each domain expressed independently of one another and together in combination as a tri-domain. The monoclonal antibody used in this assay is found to be insensitive to the single A domains and does not recognize free A1 domains as it is often assumed.
View Article and Find Full Text PDFWet deposition of atmospheric Hg in a typical inland city in North China: Sources, influencing factors, and health risk assessment.
Environ Pollut
January 2025
College of Meteorology and Oceanography, National University of Defense Technology, Changsha 410073, China.
Understanding the composition of mercury (Hg) in the atmosphere is important for confirming its sources and to preventing and reduce the production. To explore the morphological distribution characteristics of wet Hg concentrations in Xi'an Shaanxi Province, China, total Hg (THg), dissolved Hg (DTHg), reactive Hg (RTHg) and particulate-bound Hg (PTHg) (Hg insoluble in water) were measured at 72 precipitation in Xi'an from September 2020 to July 2022, and their average concentrations were 3.035 ± 3.
View Article and Find Full Text PDFThe utility of routine intraoperative CSF during ventricular shunt insertion: a 10-year retrospective cohort study.
J Neurosurg Pediatr
January 2025
1Department of Neurosurgery, Queensland Children's Hospital, Brisbane; and.
Objective: Ventricular shunt insertion is a common procedure in pediatric neurosurgical practice. In many areas of medicine there is a push toward rationalization of healthcare resources and a reduction in low-value tests or procedures. The intraoperative sampling of CSF at the time of shunt insertion is one traditional aspect of care that has not been rigorously evaluated.
View Article and Find Full Text PDFModular Synthesis of Planar-Chiral Cyclononenes via -Retentive Trapping of π-Allyl-Pd Dipoles.
J Am Chem Soc
January 2025
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P. R. China.
-cycloalkenes are abundant in bioactive natural products and have been used as powerful tools in chemical biology and drug discovery. However, strategies for the modular synthesis of -cycloalkenes, especially planar-chiral medium-sized ones, with high efficiency and selectivity, still remain elusive. Herein, we report a Pd-catalyzed asymmetric [7 + 2] cyclization strategy to address this challenge.
View Article and Find Full Text PDFA dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced and toxicity.
RSC Adv
January 2025
University of Split, Faculty of Science, Department of Chemistry R. Bošković 33 Split Croatia
Quaternary ammonium compounds (QACs) have served as essential antimicrobial agents for nearly a century due to their rapid membrane-disrupting action. However, the emergence of bacterial resistance and environmental concerns have driven interest in alternative designs, such as "soft QACs", which are designed for enhanced biodegradability and reduced resistance potential. In this study, we explored the antibacterial properties and mechanisms of action of our newly synthesized soft QACs containing a labile amide bond within a quinuclidine scaffold.
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