In the dog under pentobarbitone anesthesia, the intravenous infusion of 1 mg/kg S 2620 results in tachycardia and systemic arterial hypertension. The same attenuated effects are caused by a second injection of the drug after cervical vagotomy and chemoreceptors denervation. Tachycardia and peripheral vaso constriction can account for elevation of arterial pressure.
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