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Melatonin and abeta, macular degeneration and alzheimers disease: same disease, different outcomes?
Med Hypothesis Discov Innov Ophthalmol
March 2014
Department of Pharmacy, University of Genoa, Genova, Italy.
Aging is the common denominator and the highest risk factor for macular degeneration and Alzheimers Disease (AD). Important pathological hallmarks common to both diseases are the presence of amyloid β (Aβ) in the senile plaques of the AD brain and in the drusen of age-related macular degeneration (AMD) patients, oxidative stress, and apoptotic cell death. Data suggest that a common pathogenic mechanism might exist between AMD and AD.
View Article and Find Full Text PDFMelatonin alleviates jet lag symptoms caused by an 11-hour eastward flight.
Psychiatry Clin Neurosci
June 2002
Department of Education, Faculty of Letters, Hosei University, Tokyo, Japan.
The effect of 3 mg of melatonin on the rate of re-entrainment of plasma melatonin rhythm after an 11-h eastward flight was assessed. Eight subjects participated in the study, and underwent 24-h blood samplings once before the flight and twice after the flight. Subjects were exposed to natural zeitgeber outdoors and took 3 mg of malatonin at 20:00 h local time on the days when no blood sampling was done.
View Article and Find Full Text PDFPulse radiolysis studies of melatonin and chloromelatonin.
J Photochem Photobiol B
February 1998
Fordham University, New York, NY 10023, USA.
The endogenous indole melatonin and the melatonin receptor agonist 6-chloromelatonin block the proliferation of both dermal and uveal melanoma cells by mechanisms that may involve redox reactions. The interactions of hydrated electrons, the azide radical, hydroxyl radicals and superoxide with melatonin and its 6-chloro analogue have been studied using the technique of pulse radiolysis. The reaction rate constants of eaq- and N3 x with these compounds were found to be dependent on substitution at the sixth position.
View Article and Find Full Text PDFS.c. injection of 25 microgram of methoxytryptamine (5-MT) in oil into adult male hamsters given between 4.
View Article and Find Full Text PDFMelatonin administered to female hamsters kept under light:dark cycles of 14:10 (in hours) normally suppresses reproductive processes only if the indoleamine is administered later than 6.5 h after the beginning of the photoperiod. In the present study, we investigated the influence of morning (11.
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