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http://dx.doi.org/10.1016/s0140-6736(65)92223-3 | DOI Listing |
JCEM Case Rep
February 2025
University of Utah Health, Division of Endocrinology, Salt Lake City, UT 84108, USA.
Glucocorticoid resistance syndrome (GRS) is caused by inactivating pathogenic variants in the glucocorticoid receptor gene . Reduced glucocorticoid receptor signaling leads to decreased tissue sensitivity to cortisol and resultant biochemical hypercortisolism without the classic clinical features of Cushing syndrome. Patients variably present with signs and symptoms of mineralocorticoid and androgen excess from ACTH overstimulation of the adrenal cortex.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 83301.
Introduction: Degenerative cervical diseases can severely affect patients' quality of life (QOL), mental health, and physical function. While surgical intervention is a common treatment, its impact on holistic well-being, including spiritual health, has not been thoroughly explored. This study aimed to evaluate the effects of surgery on QOL, pain-related disability, mental health, and spiritual well-being in patients with degenerative cervical diseases.
View Article and Find Full Text PDFCureus
December 2024
Family Medicine, Holy Family Hospital, Rawalpindi, PAK.
Introduction Depression is a prevalent and debilitating condition that often requires long-term medication management. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used but have limitations in efficacy and tolerability for some individuals. New antidepressant drugs targeting multiple pathways have shown potential in recent research.
View Article and Find Full Text PDFClin Pract Epidemiol Ment Health
September 2024
School of Public Health, Al Quds University, Jerusalem, Palestine.
Background: Despite the increased interest from researchers in Postpartum depression (PPD) globally, related studies are limited in Palestine and do not provide a comprehensive understanding of PPD.
Objective: We examined the factors that determine post-partum depression among Palestinian mothers in Hebron governorate.
Methods: A cross-sectional study was conducted in 122 governmental primary healthcare clinics in Hebron Governorate.
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