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Biochemical, morphological and molecular assessments of n butanol fraction of Phoenix dactylifera L. following exposure to inorganic mercury on the liver of Wistar rats.
Lab Anim Res
April 2024
Department of Veterinary Pathology, Faculty of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Background: Mercury chloride (HgCl) damages tissues it comes in contact with in sufficient concentration. This study evaluated the protective effects of n-butanol fraction of Phoenix dactylifera (BFPD) on mercury-triggered liver toxicity in Wistar rats. 25 male rats were divided into 5 groups of 5 rats each.
View Article and Find Full Text PDFEvaluation of CD4 tumor-infiltrating lymphocyte association with some clinicopathological indices of oral squamous cell carcinoma.
Dent Res J (Isfahan)
October 2022
Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: The delayed diagnosis of oral squamous cell carcinoma (OSCC) affects therapeutic and prognostic strategies, and provides regional recurrence or distant metastasis. The tumor-infiltrating lymphocytes (TILs) are known as a critical diagnostic biomarker in antitumor immune response. We evaluated the association between CD4 T-lymphocyte marker, some clinicopathological indices, and the impact of TILs on the stage and grade of OSCC.
View Article and Find Full Text PDFThe Challenge of Teaching Essential Immunology Laboratory Skills to Undergraduates in One Month-Experience of an Osteoimmunology Course on TLR Activation.
Front Immunol
September 2020
Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, Netherlands.
Acquiring immunology laboratory skills during undergraduate studies is often a prerequisite for admission to Masters' programs. Many broad liberal arts and sciences honors degree colleges struggle in teaching these essentials since only limited time is usually reserved for this. Here, we describe a new 1-month-course developed to train a small group of honors students in 6 techniques that are useful for immunology research.
View Article and Find Full Text PDFPhylogeny of the 'orchid-like' bladderworts (gen. Utricularia sect. Orchidioides and Iperua: Lentibulariaceae) with remarks on the stolon-tuber system.
Ann Bot
November 2017
Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, Departamento de Biologia Aplicada à Agropecuária, São Paulo, Brazil.
Article Synopsis
- The study investigates the phylogenetic relationship between two sections of the orchid-like bladderworts (Utricularia), which were originally classified as one due to unclear genetic evidence.
- The research utilized DNA sequences and morphological traits from 11 species across both sections, revealing that the section Iperua is paraphyletic and closely related to Orchidioides.
- The findings suggest that the two sections should be merged, based on genetic data and histological analyses showing that their tuber systems are primarily for water storage, not supporting their distinct classification.
Dissecting asthma pathogenesis through study of patterns of cellular traffic indicative of molecular switches operative in inflammation.
Prog Stem Cell
December 2015
Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, 700019 Kolkata, West Bengal India.
Background: Inflammation and degeneration are the two edged swords that impale a pulmonary system with the maladies like asthma and idiopathic pulmonary fibrosis. To explore critical role players that orchestrate the etiology and pathogenesis of these diseases, we used various lung disease models in mice in specific genetic knockout templates.
Materials And Methods: Acute and chronic allergic asthma and idiopathic pulmonary fibrosis model in mouse was developed in various genetic knockout templates namely α4(α41-/-), β2-/-, and α4-/- β2 mice, and the following parameters were measured to assess development of composite asthma phenotype- (i) airway hyperresponsiveness to methacholine by measuring lung resistance and compliance by invasive and P by non-invasive plethysmography as well as lung resistance and compliance using invasive plethysmography, (ii) inflammation status in lung parenchyma and lung interstitium and also resultant airway remodelling measured by histochemical staining namely Masson's Trichrome staining and Hematoxylin&Eosin staining, (iii) formation of metaplastic goblet cells around lung airways by Alcian blue dye, (iv) measurement of Th1 and Th2 cytokines in serum and bronchoalveolar lavage fluid (BALf), (v) serum allergen-specific IgE.
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