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Female rat liver after sub-acute dibutyl phthalate treatment: Histological, stereological, biochemical, and global gene expression study.
Toxicol Appl Pharmacol
December 2024
University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Serbia. Electronic address:
Although it has been recognized that females are more susceptible to chemical-induced liver injury, the effects of dibutyl phthalate (DBP), a widely used synthetic chemical, on female liver structure and function are under-researched. Here, we sought to investigate the effects of DBP on histological, stereological, and biochemical parameters, as well as global gene expression in female rat liver. Female Wistar rats were exposed to 100, 500, and 5000 mg DBP/kg diet for 28 days, corresponding to 8.
View Article and Find Full Text PDFTherapeutic Potential of N-acetylcysteine and Glycine in Reducing Pulmonary Injury in Diabetic Rats.
Cureus
November 2024
Pathophysiology and Internal Medicine, University of Sarajevo, Sarajevo, BIH.
Introduction: Diabetes mellitus is associated with systemic complications, including the development of pulmonary injury, characterized mainly by excessive accumulation of extracellular matrix components and inflammatory cell infiltration in lung tissue. This process is driven by oxidative stress and chronic inflammation, both caused and exacerbated by hyperglycemia. N-acetylcysteine (NAC) and glycine, known for their antioxidant and anti-inflammatory effects, offer potential therapeutic benefits in mitigating diabetes-induced lung injury.
View Article and Find Full Text PDFAn evaluation of the effects of glabridin and dexamethasone in bleomycin-induced pulmonary fibrosis: The role of BK channels.
Tissue Cell
October 2023
Department of Pharmacology, Faculty of Medicine, Adıyaman University, Turkey.
Pulmonary fibrosis is a refractory entity with a progressive course and no effective therapeutic options. The purpose of this study was to investigate the potential involvement of both glabridin and dexamethasone (Dex) in inflammatory and fibrotic responses in a bleomycin (BLM)-induced pulmonary fibrosis model. The role of Ca-activated K channels (BK) in the anti-inflammatory effects of glabridin was also examined.
View Article and Find Full Text PDFRenal protective potential of pentoxifylline, chlorpromazine, and lovastatin in ischemia-reperfusion injury: An experimental study.
PLoS One
October 2024
Graduate Program in Veterinary Science, Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
Article Synopsis
- The study assessed the protective effects of pentoxifylline, lovastatin, and chlorpromazine against kidney damage caused by ischemia and reperfusion in animals.
- A total of 36 male animals were divided into four groups, with one group receiving no treatment and the others treated with one of the three substances.
- Results showed that while chlorpromazine was effective in the short term, pentoxifylline was the most effective overall in preserving kidney structure, with all three treatments ultimately demonstrating effectiveness.
Evaluation of the Effects of Diet-Induced Obesity in Zebrafish (): A Comparative Study.
Nutrients
October 2024
Nutrition Postgraduate Program, Center of Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
Objectives: This study aimed to compare diet-induced obesity (DIO) models in zebrafish and investigate the complications and differences between sexes in biochemical and inflammatory parameters.
Methods: Adult animals of both sexes were divided into four groups ( = 50) and fed for eight weeks: control group 1: sp. (15-30 mg/day/fish); control group 2: commercial fish food (3.
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