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Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study.
Minerva Endocrinol (Torino)
September 2023
Department of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy -
Background: Lifestyle modifications (i.e., physical activity [PA] and lower dietary intake) often are not sufficient to improve testosterone (TE) levels and promote weight loss in men with metabolic hypogonadism.
View Article and Find Full Text PDFReversible hypogonadotropic hypogonadism in men with the fertile eunuch/Pasqualini syndrome: A single-center natural history study.
Front Endocrinol (Lausanne)
November 2022
Massachusetts General Hospital - Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Boston, MA, United States.
Article Synopsis
- Congenital hypogonadotropic hypogonadism (HH) is a genetic disorder that affects puberty and fertility, with 10-15% of cases showing potential for reversal.
- A study of 240 men categorized three groups based on puberty status: fertile eunuchs (FE), absent puberty, and partial puberty; the FE group showed no history of micropenis and had distinctive hormonal profiles.
- The FE group demonstrated higher levels of gonadotropins and a significant rate of spontaneous reversal, suggesting they experience milder neuroendocrine defects compared to other HH types, highlighting the FE variant as a potential predictor for reversibility in HH.
Rates of hypogonadism forms in Klinefelter patients undergoing testicular sperm extraction: A multicenter cross-sectional study.
Andrology
November 2020
Division of Experimental Oncology/Unit of Urology, URI; RCCS Ospedale San Raffaele, Milan, Italy.
Introduction And Objectives: Adult patients with Klinefelter syndrome (KS) may present with testicular volume loss and a decrease in circulating testosterone (T) levels. However, the actual rate of hypogonadism in adult KS men is unknown. We aimed to (a) assess the prevalence of different forms of hypogonadism in a cohort of KS patients with non-obstructive azoospermia (NOA); and (b) investigate potential preoperative predictor of positive sperm retrieval (SR) at surgery in the same cohort of men.
View Article and Find Full Text PDFEnclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.
Expert Rev Endocrinol Metab
May 2019
a Department of Urology , University of Tennessee, Graduate School of Medicine, Knoxville , TN , USA.
Hypogonadism is an important issue among the male population. Treatments such as exogenous testosterone have become very popular. One of the adverse effects of testosterone is its suppression of fertility.
View Article and Find Full Text PDFObesity and male hypogonadism: Tales of a vicious cycle.
Obes Rev
August 2019
Clinical and Experimental Endocrinology, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Obesity prevalence, particularly in children and young adults, is perilously increasing worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked to impaired male gonadal function and is currently a major cause of hypogonadism. Besides signs and symptoms directly derived from decreased circulating testosterone levels, males with obesity also present poor fertility outcomes, further evidencing the parallelism between obesity and male reproductive function.
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