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Interaction of doxorubicin hydrochloride with dimethylformamide diethylacetal yielded hydrochloride of 3'-desamino-3'-dimethylformamidine doxorubicin (DFD). It was shown that with single intravenous administration to tumor-free mice DFD was 2.5 times less toxic than the initial doxorubicin.
View Article and Find Full Text PDFA blastolysin fraction, isolated from lysosyme lysates of Lactobacillus Bulgaricus strain 51 by gel chromatography, was shown to markedly inhibit the growth of sarcoma S-180. A single administration of the agent was followed by an insignificant decrease in tumor growth rate, while repeated treatment induced a complete regression of tumor in 15% of animals and resulted in a prolonged suppression of tumor growth in the others. Cells isolated from metastases which developed after the withdrawal of the drug retained susceptibility to fraction 2 of blastolysin.
View Article and Find Full Text PDFAntitumor activity of doxorubicin made in the USSR was studied on mice in respect to three transplantable tumors (lymphadenosis NK/LI, sarcoma 37 and Ehrlich's carcinoma) and hemocytoblastosis La. Doxorubicin injected intravenously 4 times was shown to be highly active against the above ascites tumors. The highest inhibitory effect of doxorubicin was observed in respect to the development of Ehrlich's carcinoma.
View Article and Find Full Text PDFTumors of various histological patterns (squamous-cell carcinoma of uterine cervix SCC. Lewis lung carcinoma, hepatoma-22a, mammary adenocarcinoma-755, sarcoma-180 and hemocytoblastosis La) were transplanted in mice aged 3, 12-18 months. Tumor SCC, hepatoma-22a, sarcoma-180 and adenocarcinoma-755 grew faster in older animals (18 months) than in younger one (3 months), while Lewis lung carcinoma and hemocytoblastosis La developed at the same rate in old and young animals.
View Article and Find Full Text PDFSeries of experiments were carried out with chickens (line 15-I and Canadian white leghorn) for establishing the oncogenic properties of Mc-29 virus strain after its multiple replication in cells transformed by it (hepatoma cells). It was established that: 1. After s.
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