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The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.
BMC Oral Health
January 2025
Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
Background: To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material.
Methods: Conventional GIC was incorporated with different concentrations of AgNW and silver nanoparticles (AgNP). Multi-species biofilms of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus fermentum, and Lactobacillus rhamnosus were cultured for 72 h on GIC specimens.
Tissue oxygenation in response to low-load and high-load back squats with continuous blood flow restriction in athletes.
J Sports Sci
January 2025
Department of Tourism, Sport and Society, Lincoln University, Christchurch, New Zealand.
To determine muscle oxygenation with continuous blood flow restriction (BFR) training in high load (HL), 80% one-repetition maximum (1RM) and low load (LL), 30% 1RM squat exercises. In week-2 of a 4-week resistance training programme as part of their 3-set training routine, two groups of athletes ( = 4 each), one performing HL training with low cuff pressure (20% arterial occlusion pressure (AOP)), the other LL training with high cuff pressure (60% AOP) had muscle oxygenation assessed with near-infrared spectrophotometry (NIRS), arterial oxygen saturation (SPO), heart rate (HR), barbell velocity and ratings of perceived exertion (RPE) during barbell back squats (BBS). Changes in the vastus lateralis oximetry were compared to pre- and post-training squat (1RM).
View Article and Find Full Text PDFUncovering the impact of COVID-19-mediated bidirectional dysregulation of cytochrome P450 3A4 on systemic and pulmonary drug concentrations using physiologically based pharmacokinetic modeling.
Drug Metab Dispos
January 2025
Current affiliation: Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Current affiliation: OneDrug Inc., Toronto, Ontario, Canada; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, United Kingdom. Electronic address:
Several clinical studies have shown that COVID-19 increases the systemic concentration of drugs in hospitalized patients with COVID-19. However, it is unclear how COVID-19-mediated bidirectional dysregulation of hepatic and pulmonary cytochrome P450 (CYP) 3A4 affects drug concentrations, especially in the lung tissue, which is most affected by the disease. Herein, physiologically based pharmacokinetic modeling was used to demonstrate the differences in systemic and pulmonary concentrations of 4 respiratory infectious disease drugs when CYP3A4 is concurrently downregulated in the liver and upregulated in the lung based on existing clinical data on COVID-19-CYP3A4 interactions at varying severity levels including outpatients, non-intensive care unit (ICU), and ICU patients.
View Article and Find Full Text PDFImpact of an urban city-wide Bradford Clean Air Plan on health service use and nitrogen dioxide 24 months after implementation: An interrupted time series analysis.
Environ Res
January 2025
Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford, UK, BD9 6RJ; Population Health Improvement UK (PHI-UK).
There is limited evidence of the health impact of Low Emission Zones (also known as Clean Air Zones, CAZ). This study examines the impact of the Bradford Clean Air Plan (CAP), including a CAZ, on health and nitrogen dioxide (NO) in the first two years of implementation using an interrupted time series design. Primary care and emergency department visits for respiratory and cardiovascular illness in Bradford were recorded between January 2018 to September 2023 with diabetic footcare and head injury visits as controls.
View Article and Find Full Text PDFNEONATAL CO-ADMINISTRATION OF THE PHYTOESTROGENS GENISTEIN AND DAIDZEIN DISRUPTS SEXUAL BEHAVIOR AND FERTILITY.
Physiol Behav
January 2025
Departamento de Biología de la Reproducción. D.C.B.S, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, C.P, 09340, Ciudad de México, México. Electronic address:
Phytoestrogens are non-steroidal compounds that, can act as agonists and/or antagonists by binding to estrogen receptors; hence they can modify estrogen-dependent processes of neonatal sexual differentiation. Results of the analysis of the sexual behavior of experimental rats that received 6.8 mg of isoflavones/kg/day, showed significantly more mating activity, but fewer ejaculations (p<0.
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