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A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty.
Adv Ther
December 2024
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei,, China.
Article Synopsis
- - This phase 3 study evaluated a 6-month prolonged release formulation of triptorelin for treating central precocious puberty (CPP) in Chinese children, focusing on its efficacy, safety, and pharmacokinetics.
- - In an open-label trial involving 66 children (93.9% girls), the treatment successfully suppressed luteinizing hormone (LH) levels in all participants by month 6, with 98.5% maintaining this suppression at month 12, alongside other positive hormone and development outcomes.
- - The study found that triptorelin had a safety profile similar to previous studies in non-Chinese children, with limited adverse events reported, reinforcing its effectiveness and safety in managing CPP.
Arts-based analysis of conservation education field trips for young people to observe wild lemurs in Southern Madagascar.
Folia Primatol (Basel)
October 2024
Red Book Challenge Conservation Education Madagascar, 97 Elgin Avenue East Goderich, ON, N7A 1K5, Canada.
Opportunities for young people to directly experience nature can have positive impacts on the individual, the social group and on society as a whole, through future increased conservation action. We developed a program which engaged young people from Fort Dauphin in a field trip to see wild animals at Nahampoana Reserve. Our aim in offering field trips to young people living in the city was to create a positive emotional opportunity to engage directly with nature with the ultimate goal of protecting lemurs and their habitat.
View Article and Find Full Text PDFComparing spatial differences in behavioral pattern transition of Black-tailed gull during post breeding season in the Korean peninsula.
Sci Rep
August 2024
Division for Natural Environment, Korea Environment Institute, Sejong, 30147, Republic of Korea.
Parents adjust their foraging effort according to the chick and their own body condition and dual foraging strategy is one of the foraging tactics parents replenish their own reserves while feeding their chicks. During the post-breeding season, seabirds disperse to recover their own body condition and prepare for the next breeding season. Recently, we discovered Black-tailed gulls (Larus crassirostris) breeding around the Korean Peninsula occasionally foraging long trips during the late fledging, however, our understanding of the behavioral patterns of Black-tailed gulls during the late fledging and post-breeding, as well as its inter-colonial differences, remains considerably limited.
View Article and Find Full Text PDFConcerns about vaccines and vaccination behavior among Japanese budget travelers to India.
J Infect Chemother
January 2025
Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan. Electronic address:
Background: Low vaccination coverage among travelers poses a critical challenge to global health security. Indeed, public concerns regarding vaccines can lead to vaccine reluctance and refusal, but evidence about the impacts of concerns regarding vaccines on the uptake of travel vaccinations remains sparse. We examined the associations between concerns about vaccines and vaccination behavior among travelers.
View Article and Find Full Text PDFNeuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo.
Nat Ment Health
January 2024
Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In the COORDINATE-MDD consortium, raw MRI data were shared from international samples ( = 1,384) of medication-free individuals with first-episode and recurrent MDD ( = 685) in a current depressive episode of at least moderate severity, but not treatment-resistant depression, as well as healthy controls ( = 699).
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