The uptake of selenodiglutathione and selenodicysteine was compared to that of selenite by brush border membrane vesicles (BBMV) prepared from rat intestinal tracts. It was found that it is critical to maintain a pH of 6.0 or below to prevent the spontaneous breakdown of these compounds. When conducted at pH 6.0, the uptake of selenodiglutathione and selenodicysteine was more than ten times faster than for selenite selenium. Ligated intestinal loop studies were conducted to determine if similar results would be obtained in vivo. In comparison to selenite, selenium absorption was enhanced 68% and the transfer to the body increased 2.4-fold when selenium as selenodiglutathione was placed in the ileum. The absorption of selenium as selenodicysteine was increased by 57% and the transfer doubled in comparison to selenite when placed in the ileum. Thus, the stimulated absorption of selenite by glutathione or cysteine appears to be through the formation of complexes with these compounds.
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http://dx.doi.org/10.1016/0162-0134(92)84049-s | DOI Listing |
J Hazard Mater
January 2025
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China. Electronic address:
The Mercury (II) ion (Hg²⁺) is a toxic heavy metal that threatens biological systems by inducing oxidative stress and disrupting the redox balance. Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are critical in maintaining redox homeostasis and are implicated in numerous physiological and pathological processes. Understanding the complex interactions between Hg²⁺ and biothiols requires molecular tools capable of simultaneous detection.
View Article and Find Full Text PDFJ Pharm Biomed Anal
January 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 48, Münster 48149, Germany. Electronic address:
Minocycline is an antibiotic of the tetracycline family which is widely used to treat a range of medical conditions. Although it has been in use for more than 50 years, little information is available on its metabolism in the human body. In this study, we simulate the biotransformation of minocycline by means of electrochemistry coupled to mass spectrometry.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.
Methods: To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.
Biochimie
January 2025
Jagiellonian University Medical College, Faculty of Health Sciences, Department of Medical Physiology, Chair of Biomedical Sciences, 12 Michalowskiego st., 33-332 Cracow, Poland.
Obesity treatment requires an individualized approach, emphasizing the need to identify metabolic pathways of diagnostic relevance. Toll-like receptors (TLRs), particularly TLR2 and TLR4, play a crucial role in metabolic disorders, as receptor deficiencies improves insulin sensitivity and reduces obesity-related inflammation. Additionally, hydrogen sulfide (HS) influences lipolysis, adipogenesis, and adipose tissue browning through persulfidation.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Sulfur-containing small molecules, mainly including cysteine (Cys), homocysteine (Hcy), glutathione (GSH), and hydrogen sulfide (HS), are crucial biomarkers, and their levels in different body locations (living cells, tissues, blood, urine, saliva, ) are inconsistent and constantly changing. Therefore, it is highly meaningful and challenging to synchronously and accurately detect them in complex multi-component samples without mutual interference. In this work, we propose a steric hindrance-regulated probe, NBD-2FDCI, with single excitation dual emissions to achieve self-adaptive detection of four analytes.
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