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3D human stem-cell-derived neuronal spheroids for neurotoxicity testing of methylglyoxal, highly reactive glycolysis byproduct and potent glycating agent.
Curr Res Toxicol
June 2024
Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Pavia, Italy.
Article Synopsis
- The study investigates the cytotoxic effects of methylglyoxal (MGO) on human-derived 3D neuronal spheroids, a model that mimics human brain cells, particularly in relation to aging and neurodegenerative diseases.
- Results show that MGO leads to decreased cell viability and growth at low concentrations, with significant cellular damage observed at higher doses, including necrosis and apoptosis.
- The findings highlight the potential of using these complex 3D models to evaluate the impact of MGO and other harmful agents, providing insights into mechanisms of neurodegeneration and aging.
Overview of crosstalk between stromal and epithelial cells in the pathogenesis of adenomyosis and shared features with deep endometriotic nodules.
Hum Reprod
August 2024
Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
Since the first description of adenomyosis more than 150 years ago, multiple hypotheses have attempted to explain its pathogenesis. Indeed, research over recent years has greatly enhanced our knowledge of the underlying causes. This has opened up avenues for the development of strategies for both disease prevention and treatment of its main symptoms, such as pelvic pain, heavy menstrual bleeding, and infertility.
View Article and Find Full Text PDFOntogeny of the pollinium in Hoya carnosa provides new insights into microsporogenesis.
Plant Reprod
June 2023
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, 510650, Guangzhou, People's Republic of China.
The presence of a pollinium is a distinct character in Apocynaceae which is important for phylogenetic analysis. The pollinium of Hoya has an outer sporopollenin wall and a pellucid margin which are adaptive features. However, their ontogeny and related evolutionary implications are not entirely understood.
View Article and Find Full Text PDFThe Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility.
PLoS Biol
May 2022
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Inherited microorganisms can selfishly manipulate host reproduction to drive through populations. In Drosophila melanogaster, germline expression of the native Wolbachia prophage WO proteins CifA and CifB cause cytoplasmic incompatibility (CI) in which embryos from infected males and uninfected females suffer catastrophic mitotic defects and lethality; however, in infected females, CifA expression rescues the embryonic lethality and thus imparts a fitness advantage to the maternally transmitted Wolbachia. Despite widespread relevance to sex determination, evolution, and vector control, the mechanisms underlying when and how CI impairs male reproduction remain unknown and a topic of debate.
View Article and Find Full Text PDFDesign of an Innovative Methodology for Cerebrospinal Fluid Analysis: Preliminary Results.
Sensors (Basel)
May 2021
Department of Science and Technology for Humans and the Environment, Campus Bio-Medico, University of Rome Italy, 00128 Rome, Italy.
Cerebrospinal fluid (CSF) analysis supports diagnosis of neurodegenerative diseases (NDs), however a number of issues limits its potentialities in clinical practice. Here, a newly developed technique for fluid voltammetry, relying on a simple sensor (BIOsensor-based multisensorial system for mimicking Nose, Tongue and Eyes, BIONOTE), was used to test the applicability for CSF analysis. BIONOTE was initially calibrated on an artificial CSF-like solution and then applied on human CSF, either immediately after collection or after refrigerated storage.
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