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DDIT3 switches osteogenic potential of BMP9 to lipogenic by attenuating Wnt/β-catenin signaling via up-regulating DKK1 in mesenchymal stem cells.
Aging (Albany NY)
September 2024
Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing 400016, China.
Bone morphogenetic protein 9 (BMP9) functions as a potent inducer of osteogenic differentiation in mesenchymal stem cells (MSCs), holding promise for bone tissue engineering. However, BMP9 also concurrently triggers lipogenic differentiation in MSCs, potentially compromising its osteogenic potential. In this study, we explored the role of DNA damage inducible transcript 3 (DDIT3) in regulating the balance between BMP9-induced osteogenic and lipogenic differentiation in MSCs.
View Article and Find Full Text PDFIncreased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation.
PLoS One
June 2024
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States of America.
Article Synopsis
- Gallbladder disease in dogs, specifically mucocele formation, is linked to abnormal lipid metabolism and is characterized by unusual mucus secretion.
- A study involving 18 affected dogs and 18 controls utilized lipid analysis techniques to investigate potential causes of the disease.
- The research found a distinctive lipid profile in affected dogs with increased lipogenesis, suggesting that altered lipid metabolism plays a key role in the development of gallbladder mucocele formation.
Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Eur J Clin Invest
July 2024
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Background: The role of insulin resistance in hepatic fibrosis in Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of insulin resistance and steatohepatitis in AlbuminCre + Cc1 mice with liver-specific mouse gene encoding CEACAM1 protein (Ceacam1) deletion. We herein investigated whether these mice also developed hepatic fibrosis and whether hepatic CEACAM1 is reduced in patients with MASH at different fibrosis stages.
View Article and Find Full Text PDFInterplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.
J Cancer
October 2019
Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Protein kinase D (PKD) has been implicated in cancer cell survival, proliferation, migration and angiogenesis. However, it is still unknown whether PKD regulates cell proliferation through lipid metabolism in cancer cells. Here we report a novel function of PKD3, a member of PKD family, in regulating of prostate cancer cell proliferation by modulation of SREBP1-mediated lipogenesis.
View Article and Find Full Text PDFHepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease.
Nutrients
June 2018
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34053, Korea.
Insects represent the largest and most diverse group of organisms on earth and are potential food and drug resources. Recently, we have demonstrated that a extract prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we aimed to evaluate the hepatoprotective effects of extracts of the insects Kolbe, 1886 (PB), Mishchenko, 1951 (OC), and De Geer, 1773 (GB) in a high-fat diet (HFD)-induced NAFLD animal model, as well as to elucidate the underlying mechanisms.
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