Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Hypercalcaemia in association with Sertoli cell tumour in a dog.
J Small Anim Pract
January 2025
Department of Veterinary Medicine and Surgery, University of Missouri, College of Veterinary Medicine, Columbia, Missouri, USA.
A 9-year-old, presumed male castrated mixed breed dog was evaluated for lethargy, hyporexia, polyuria, polydipsia and diffuse gynaecomastia. Bloodwork revealed severe hypercalcaemia and hyposthenuria. CT scan showed a caudal abdominal mass consistent with a Sertoli cell tumour on cytology.
View Article and Find Full Text PDFEndocrine Hormones and Their Impact on Pubertal Gynecomastia.
J Clin Med
December 2024
Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100144, China.
Pubertal gynecomastia (PG) is a common condition characterized by the abnormal development and hyperplasia of unilateral or bilateral breast tissue in adolescent males, affecting up to 50% of appropriately aged adolescents and exhibiting rising prevalence over recent years. The etiology of PG is multifaceted, encompassing physiological, pharmacological, and pathological factors. This narrative review synthesizes evidence from a comprehensive selection of peer-reviewed literature, including observational studies, clinical trials, systematic reviews, and case reports, to explore the pivotal role of endocrine hormones in the pathogenesis of PG.
View Article and Find Full Text PDFClinical implications of mineralocorticoid receptor overactivation.
Clin Kidney J
January 2025
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
The mineralocorticoid receptor (MR) is a nuclear transcription factor that plays a critical role in regulating fluid, electrolytes, blood pressure, and hemodynamic stability. In conditions such as chronic kidney disease (CKD) and heart failure (HF), MR overactivation leads to increased salt and water retention, inflammatory and fibrotic gene expression, and organ injury. The MR is essential for transcriptional regulation and is implicated in metabolic, proinflammatory, and pro-fibrotic pathways.
View Article and Find Full Text PDFMale Breast Cancer Biology, Screening, Treatment, and Follow-Up: A Narrative Review.
Iran J Public Health
December 2024
Research Center of Integrative Medicine, Ageing Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- Male breast cancer (MBC) is rare, making up only 1% of cancers in men and often diagnosed in older males who may confuse symptoms with gynecomastia.
- Treatment guidelines for MBC are often based on studies of female breast cancer due to the lack of specific research and clinical trials for men.
- Management typically involves surgical intervention, possibly followed by radiotherapy and other therapies, but effective screening for MBC remains limited due to insufficient data on its impact on mortality.
Bone Disease Associated with Inactivating Aromatase Mutations and its Management.
Calcif Tissue Int
January 2025
Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Santa Maria Alle Scotte, Siena, Italy.
Article Synopsis
- Aromatase deficiency is a rare genetic disorder caused by mutations in the CYP19A1 gene, affecting both males and females, with an incidence of less than 1 in 1,000,000.
- In females, symptoms typically present at birth or in early infancy, focusing on sexual development, while in males, issues usually emerge during or after puberty, leading to delayed diagnosis.
- The paper reviews the skeletal and extraskeletal effects of the condition and discusses strategies for managing bone health in individuals with these mutations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!