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New endocrine method of oral male contraception.
Contraception
December 2024
R&D Department, Pandora Endocrine Innovation, Bergen, Netherlands. Electronic address:
Essential for hormonal male contraception (HMC) is the inhibition of follicle-stimulating hormone (FSH), the hormone responsible for spermatogenesis. No drugs exist that can selectively suppress FSH without also inhibiting luteinizing hormone (LH), the hormone responsible for the biosynthesis of testosterone (T) and estradiol (E2) in men. The consequences are a loss of T and E2, with the accompanying symptoms and signs of T deficiency and E2 deficiency, respectively.
View Article and Find Full Text PDFNOX4 deficiency improves the impaired viability, inhibited the apoptosis and suppressed autophagy of DHEA-treated ovarian granulosa cells through inhibiting endoplasmic reticulum stress via inactivating PERK/ATF4 pathway.
Tissue Cell
February 2025
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province 250014, China. Electronic address:
Background: PCOS is the most prevalent endocrine and metabolic problem in women of reproductive age. This current study was formulated to thoroughly expound the ovary-protecting effects of NOX4 deficiency in PCOS and probe into the intrinsic mechanisms underlying the protective effects of NOX4 deficiency against DHEA injury in ovarian GCs.
Methods: KGN cells were subjected to 20 nM DHEA for 48 h to establish PCOS cellular model.
The role of anti-aging approaches in managing hypogonadism in sedentary older males.
Front Aging
November 2024
Faculty of Dentistry, Mutah University, Karak, Jordan.
Article Synopsis
- About 30% of the global population lacks sufficient exercise, contributing significantly to premature death and age-related health issues, especially in individuals over 80.
- The study aims to explore the connection between anti-aging strategies and testosterone levels in older, sedentary men, emphasizing the potential pharmacological interventions.
- Findings suggest a negative cycle between inactivity and low testosterone, with anti-aging methods like exercise, a healthy diet, and testosterone replacement therapy showing promise in improving health outcomes and mitigating age-related diseases.
Zuogui pills ameliorate chemotherapy-induced ovarian aging by improving stemness, regulating cell cycle and reducing apoptosis of oogonial stem cells via the Notch1/Nrf2 pathway.
J Ethnopharmacol
January 2025
Department of Gynecology, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:
Ethnopharmacological Relevance: Zuogui Pills (ZGP) is a classic traditional Chinese herbal formula originating from the Ming Dynasty. It has been widely used in the treatment of kidney deficiency-related diseases, including ovarian aging.
Aim Of The Study: To investigate the effects and potential mechanisms of ZGP on ovarian aging induced by the chemotherapeutic agent cyclophosphamide (CTX), as well as its impact on the therapeutic target, oogonial stem cells (OSCs), involving the Notch1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Delayed Emergence of Isolated Secondary Adrenal Insufficiency: A Case Report.
Cureus
October 2024
Family Medicine, Baptist Health of South Florida, Miami, USA.
Article Synopsis
- Secondary adrenal insufficiency (SAI) is a rare condition caused by a deficiency in the adrenocorticotropic hormone (ACTH) from the pituitary gland, leading to symptoms like chronic low sodium levels (hyponatremia), and can present a diagnostic challenge, particularly when there are no identifiable triggers.
- An 80-year-old woman with a history of multiple health issues was diagnosed with isolated adrenal insufficiency after presenting with weakness and fatigue, leading to complications that required specific treatments including corticosteroids.
- This case highlights the importance of recognizing atypical presentations of adrenal insufficiency, as well as the effectiveness of corticosteroid replacement therapy in resolving symptoms and normalizing sodium levels.
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