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Crystal structure of ()--cyclo-hexyl-2-(2-hy-droxy-3-methyl-benzyl-idene)hydrazine-1-carbo-thio-amide.
Acta Crystallogr E Crystallogr Commun
July 2019
School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia.
The asymmetric unit of the title compound, CHNOS, comprises of two crystallographically independent mol-ecules ( and ). Each mol-ecule consists of a cyclo-hexane ring and a 2-hy-droxy-3-methyl-benzyl-idene ring bridged by a hydrazinecarbo-thio-amine unit. Both mol-ecules exhibit an configuration with respect to the azomethine C=N bond.
View Article and Find Full Text PDF()-2-(2-Hy-droxy-3-methyl-benzyl-idene)--methyl-hydrazine-1-carbo-thio-amide: supra-molecular assemblies in two-dimensions mediated by N-H⋯S and C-H⋯π inter-actions.
Acta Crystallogr E Crystallogr Commun
May 2019
School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia.
In the title compound, CHNOS, the azomethine C=N double bond has an configuration. The phenyl ring and methyl-hydrazine carbo-thio-amide moiety [maximum deviation = 0.008 (2) Å] are twisted slightly with a dihedral angle of 14.
View Article and Find Full Text PDFSynthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides.
Eur J Med Chem
January 2018
Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan. Electronic address:
Three series of 4-hydroxy-N-[benzylidene/1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides (9-11)a-l were synthesized and unraveled to be highly potent dual inhibitors of monoamine oxidases (MAO-A and MAO-B). All the examined compounds demonstrated IC values in lower micro-molar range for both MAO-A as well as MAO-B. The most active MAO-A inhibitor was 4-hydroxy-N'-(1-phenylethylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxide (9i) with an IC value of 0.
View Article and Find Full Text PDF1,2-Bis(2-hy-droxy-5-methyl-benzyl-idene)hydrazine.
Acta Crystallogr Sect E Struct Rep Online
January 2014
Centre for Research and Development, PRIST University, Vallam, Thanjavur 613 403, India.
The mol-ecular structure of the title compound, C16H16N2O2, is stabilized by intra-molecular O-H⋯N hydrogen bonds with S(6) graph-set motifs, so that the mol-ecule is almost planar, with a C=N-N=C torsion angle of -179.7 (2)° and a dihedral angle of 1.82 (12)° between the aromatic rings.
View Article and Find Full Text PDF5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities.
Chemistry
April 2010
Institut Pasteur, URA 2128 CNRS-Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex 15 (France), Fax: (+33) 145688404.
Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of ethyl 3-ethoxy-1H-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and diethyl 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole.
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