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An increase of blood and plasma viscosity, an increased aggregation of erythrocytes and a decreased deformability of erythrocytes are pathogenetically important for a disturbance of the microcirculation. In rigidity of the vascular wall due to vasosclerosis according to Hagen-Poiseuille's law the fluidity of blood essentially determines the size of blood circulation, and a reduced blood flow by an impairment to the nutritive capillary blood supply leads to hypoxic tissue damages. For a series of pictures of a disease, such as polycythaemias, anaemias, paraproteinoses, diabetes mellitus, Raynaud's syndrome, myocardial infarction, degenerative angiopathies, are changes of the blood rheology of clinical relevancy.

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Report on paraprotein-cases in a dermatological totality of patients during a six years period. Among 860 seras we found 22 cases with paraproteins. Except IgE-paraprotein all other paraproteinclasses were found in their natural multidy.

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