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Late metastasis of rectal adenocarcinoma to the penis.

BMJ Case Rep

November 2024

Urology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Rectal cancer metastasising to the penis is an exceptionally rare clinical entity, with less than 80 reported cases. Metastasis to the penis is typically identified in conjunction with widespread metastatic disease and as such is usually associated with a very poor prognosis. We report a case of a man who presented with a metastatic deposit in his penis 15 years after the initial diagnosis of rectal cancer.

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The penis is a relatively uncommon organ for metastases. Secondary lesions often originate from the bladder, prostate, or rectosigmoid cancers. Only a few cases have described penile lesions secondary to lung cancers, mostly as a later complication.

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Article Synopsis
  • Extramammary Paget disease (EMPD) is a rare type of skin cancer that mainly affects areas with apocrine glands like the vulva, scrotum, and penis, and often has a poor prognosis, especially with distant metastases.
  • Patients with localized EMPD generally have a good 5-year survival rate between 60%-92%, while those with metastases only have about a 10% survival rate.
  • A case report highlights a 57-year-old man with metastatic EMPD who responded well to a combination of an immune checkpoint inhibitor and chemotherapy, suggesting this approach may improve outcomes for others with similar advanced disease.*
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Sarcopenia, defined as age-associated loss of skeletal muscle function and muscle mass, is a negative prognostic marker for survival in several tumor entities. However, data evaluating the impact of sarcopenia and fat distribution on penile cancer are rarely described. We performed a retrospective study including 38 patients who were diagnosed with squamous cell carcinoma of the penis.

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Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract, usually arising in the stomach or in the small bowel. Most GISTs are diagnosed early due to the presence of symptoms (e.g.

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