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Prolonged Neuromuscular Blockade Following Succinylcholine Administration and the Clinical Importance of Family History: A Case Report.
Cureus
February 2025
Anesthesiology, HCA Florida Westside Hospital, Plantation, USA.
When evaluating the etiology of delayed emergence from anesthesia, several differential diagnoses must be considered, with family history often being an overlooked factor. This case report highlights the clinical significance and diagnostic challenges of one such differential - pseudocholinesterase deficiency (PD). PD is a known defect in the pseudocholinesterase enzyme that may be either inherited or acquired.
View Article and Find Full Text PDFImproved genetic screening with zygosity detection through multiplex high-resolution melting curve analysis and biochemical characterisation for G6PD deficiency.
Trop Med Int Health
March 2025
Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia (UTM), Johor Bahru, Malaysia.
Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is crucial for relapse malaria treatment using 8-aminoquinolines (primaquine and tafenoquine), which can trigger haemolytic anaemia in G6PD-deficient individuals. This is particularly important in regions where the prevalence of G6PD deficiency exceeds 3%-5%, including Southeast Asia and Thailand. While quantitative phenotypic tests can identify women with intermediate activity who may be at risk, they cannot unambiguously identify heterozygous females who require appropriate counselling.
View Article and Find Full Text PDFMachine Learning-Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent.
Chem Biol Drug Des
March 2025
School of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, China.
The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Therefore, it is an important target for antibacterial drug research.
View Article and Find Full Text PDFInterplay Between Diet, Branched-Chain Amino Acids, and Myokines in Children: Vegetarian Versus Traditional Eating Habits.
Nutrients
February 2025
Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland.
The quality and composition of dietary proteins are crucial during growth, particularly in children who follow vegetarian diets. Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) and lysine play essential roles in muscle growth, repair, and metabolism and are involved in the regulation of muscle-derived proteins known as myokines. This study aimed to compare the dietary intake and circulating levels of BCAAs, lysine, and myokines-follistatin-like protein 1 (FSTL-1), myostatin, and myonectin-between vegetarian and omnivorous prepubertal children and to explore the impact of diet on muscle metabolism.
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