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Lactoferrin Attenuates Intestinal Barrier Dysfunction and Inflammation by Modulating the MAPK Pathway and Gut Microbes in Mice.
J Nutr
November 2022
College of Animal Science and Technology, Yangzhou University, Yangzhou, PR China. Electronic address:
Background: Deoxynivalenol (DON) is a major mycotoxin present in staple foods (particularly in cereal products) that induces intestinal inflammation and disrupts intestinal integrity. Lactoferrin (LF) is a multifunctional protein that contributes to maintaining intestinal homeostasis and improving host health. However, the protective effects of LF on DON-induced intestinal dysfunction remain unclear.
View Article and Find Full Text PDFCentral nervous system neurotoxicity associated with nelarabine in T-cell acute lymphoblastic leukemia.
J Oncol Pharm Pract
January 2023
Department of Radiology, 63988Cukurova University School of Medicine, Adana, Turkey.
Introduction: Nelarabine, a prodrug of arabinosylguanine has lineage-specific toxicity for T lymphoblasts and is used to treat refractory or relapsed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma patients. The most commonly observed adverse effects associated with nelarabine are mainly hematological, i.e.
View Article and Find Full Text PDFA Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic .
Toxins (Basel)
March 2022
Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
uses cholera toxin (CT) to cause cholera, a severe diarrheal disease in humans that can lead to death within hours of the onset of symptoms. The catalytic activity of CT in target epithelial cells increases cellular levels of 3',5'-cyclic AMP (cAMP), leading to the activation of the cystic fibrosis transmembrane conductance regulator (CFTR), an apical ion channel that transports chloride out of epithelial cells, resulting in an electrolyte imbalance in the intestinal lumen and massive water loss. Here we report that when administered perorally, benzopyrimido-pyrrolo-oxazinedione, (R)-BPO-27), a potent small molecule inhibitor of CFTR, blocked disease symptoms in a mouse model for acute diarrhea caused by toxigenic .
View Article and Find Full Text PDFLead encephalopathy in an adult opioid abuser.
BMJ Case Rep
September 2021
Department of Haematology, Aga Khan University Hospital, Karachi, Pakistan.
A 38-year-old man presented at the emergency department with abdominal pain, vomiting, generalised weakness and altered consciousness. He had been ingesting opioids for over 5 years and had several past hospital admissions for abdominal pain. His investigations showed deranged liver function tests, anaemia and basophilic stippling on the peripheral blood smear.
View Article and Find Full Text PDFPeptidase PepP is a novel virulence factor of contributing to murine campylobacteriosis.
Gut Microbes
November 2020
Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen/Nuremberg, Erlangen, Germany.
Mechanisms of host-pathogen interactions resulting in immunopathological responses upon human infection are not completely understood, but the recent availability of murine infection models mimicking key features of campylobacteriosis helps solving this dilemma. During a screen for proteases expressed by , we identified a peptidase of the M24 family as a potential novel virulence factor, which was named PepP. The gene is strongly conserved in various species.
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