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The pathogenesis of gout.
J Rheum Dis
January 2025
Division of Rheumatology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Gout is the most common inflammatory arthritis in adults, associated with hyperuricemia and the chronic deposition of monosodium urate (MSU) crystals. Hyperuricemia results from increased production of uric acid and decreased excretion by the kidneys and intestines. Urate excretion is regulated by a group of urate transporters, and decreased renal or intestinal excretion is the primary mechanism of hyperuricemia in most people.
View Article and Find Full Text PDFProposed biosensor for the detection of Bovine Serum Albumin using 7CB liquid crystals: A preliminary study.
Int J Biol Macromol
December 2024
Department of Physics, National Institute of Technology, Meghalaya, India. Electronic address:
Liquid crystal (LC) based biosensors offer a sensitive platform for detecting biomolecules due to their ability to respond to molecular interactions through changes in LC orientations. In this paper, we introduce a novel LC biosensor using 4-heptyl-4-biphenyl carbonitrile (7CB) to detect Bovine Serum Albumin (BSA). The interaction between BSA and 7CB was investigated using polarising optical microscopy (POM), molecular docking (MD), and Raman spectroscopy.
View Article and Find Full Text PDFMonitoring conformational changes in the human neurotransmitter transporter homologue LeuT with F-NMR spectroscopy.
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Associate Laboratory i4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
Neurotransmitter:sodium symporters (NSS) reuptake neurotransmitter molecules from the synaptic space through Na-coupled transport. They are thought to work via the alternating access mechanism, exploring multiple configurations dictated by the binding of substrates and ions. Much of the current knowledge about these transporters has been derived from examining the structure of the Leucine Transporter (LeuT), a bacterial counterpart to human NSSs.
View Article and Find Full Text PDFPirfenidone microcrystals for pulmonary delivery: Regulation of the precipitation behavior in the supercooled droplet.
Int J Pharm
January 2025
Engineering Research Centre of Advanced Powder Technology (ERCAPT), School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province 215123, PR China. Electronic address:
Pirfenidone (PFD) is one of the first-line drugs for treating idiopathic pulmonary fibrosis, while directly delivering PFD to lung showed better efficiency. However, PFD is a non-glass former and easily precipitates into larger-sized crystals that are undesirable for pulmonary delivery. Hence, the fabrication of PFD particles with pulmonary delivery efficiency remains challenging.
View Article and Find Full Text PDFThe High-Resolution Structure of a Variable Lymphocyte Receptor From Petromyzon marinus Capable of Binding to the Brain Extracellular Matrix.
Proteins
November 2024
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Variable lymphocyte receptors (VLRs) are antigen receptors derived from the adaptive immune system of jawless vertebrates such as lamprey (Petromyzon marinus). First discovered in 2004, VLRs have been the subject of numerous biochemical and structural investigations. Due to their unique antigen binding properties, VLRs have been leveraged as possible drug delivery agents.
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