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The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study.
Ann Med
December 2025
Department of Medical Imaging, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, France.
Objective: The objective of this study was to explore the ability of dual-energy computed tomography (DECT) to detect monosodium urate (MSU) crystal deposits in the kidneys and renal artery walls, and uric acid urolithiasis, in patients with gout and chronic kidney disease (CKD).
Methods: Patients with gout and with stage 2-4 CKD were prospectively included in this cross-sectional study. Patients underwent renal, knee and feet DECT scans.
Development and Validation of an Ultrasound-Based Clinical Radiomics Nomogram for Diagnosing Gouty Arthritis.
Ultrasound Med Biol
January 2025
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China; Fuzhou University Affiliated Provincial Hospital, Department of Ultrasound, Fuzhou, Fujian Province, China. Electronic address:
Objective: This study aimed to develop and validate a diagnostic model for gouty arthritis by integrating ultrasonographic radiomic features with clinical parameters.
Methods: A total of 604 patients suspected of having gouty arthritis were enrolled and randomly divided into a training set (n = 483) and a validation set (n = 121) in a 4:1 ratio. Univariate and multivariate analyses were conducted on the clinical data to identify statistically significant clinical features for constructing an initial diagnostic model.
Relationship between serum urate and changes in dual-energy CT monosodium urate crystal volume over 1 year in people with gout: an individual participant data analysis.
Ann Rheum Dis
January 2025
Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address:
Objectives: The dynamics of monosodium urate (MSU) crystal changes across a range of serum urate concentrations in people with gout are unknown. This study aimed to systematically examine the relationship between serum urate and changes in dual-energy CT (DECT) urate volume in people with gout and stable serum urate concentrations.
Methods: Individual participant data were analysed from three studies of people with gout.
Advances in the use of nanotechnology for treating gout.
Nanomedicine (Lond)
January 2025
Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, P. R. China.
Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels of uric acid. Its incidence rate rises with the increases of living standards and poor dietary habits, which has a considerable impact on the quality of life of the patients. Although there is a wide assortment of drugs available for the management of gout, the effectiveness and security of these drugs are limited by their poor chemical stability and insufficient targeting.
View Article and Find Full Text PDFCurrent Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach.
Pharmaceutics
January 2025
Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia.
The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines.
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