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Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM.
Cell Rep
January 2025
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address:
One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors. Despite significant advances in understanding the mechanisms of HIV-1 CA assembly and host factor interactions, HIV-2 CA assembly remains poorly understood. By templating the assembly of HIV-2 CA on functionalized liposomes, we report high-resolution structures of the HIV-2 CA lattice, including both CA hexamers and pentamers, alone and with peptides of host phenylalanine-glycine (FG)-motif proteins Nup153 and CPSF6.
View Article and Find Full Text PDFAtomically thin high-entropy oxides via naked metal ion self-assembly for proton exchange membrane electrolysis.
Nat Commun
January 2025
School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Designing efficient Ruthenium-based catalysts as practical anodes is of critical importance in proton exchange membrane water electrolysis. Here, we develop a self-assembly technique to synthesize 1 nm-thick rutile-structured high-entropy oxides (RuIrFeCoCrO) from naked metal ions assembly and oxidation at air-molten salt interface. The RuIrFeCoCrO requires an overpotential of 185 mV at 10 m A cm and maintains the high activity for over 1000 h in an acidic electrolyte via the adsorption evolution mechanism.
View Article and Find Full Text PDFEnhancement of mechanical properties in reactive polyurethane film via in-situ assembly of embedded cellulose nanocrystals.
Int J Biol Macromol
January 2025
Zhejiang Provincial Engineering Research Center for Green and Low-carbon Dyeing & Finishing, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang Provincial Innovation Center of Advanced Textile Technology, Shaoxing 312000, China. Electronic address:
Comparing to the solvent-based and waterborne polyurethanes (PU), the solvent-free reactive PU (RPU) is prepared via in-situ polymerization and film-formation of isocyanate-capped prepolymers and macromolecular polyols in solvent-free system. Thus, the carbon emissions and environmental pollutions are significantly reduced. However, the rapid polymerization also challenges the well control of structure and properties, especially the ordered microstructures.
View Article and Find Full Text PDFLongitudinal integrated proteomic and metabolomic skin changes in atopic dermatitis patients treated with dupilumab.
J Allergy Clin Immunol
January 2025
National Jewish Health, Denver, CO, USA. Electronic address:
Background: Inhibition of IL-4/IL-13 driven inflammation by dupilumab has shown significant clinical benefits in treatment of atopic dermatitis (AD).
Objective: To assess longitudinal protein and metabolite composition in AD skin during dupilumab treatment.
Methods: Skin tape strip (STS) were collected from lesional/non-lesional skin of 20 AD patients during 16-week dupilumab treatment and from 20 healthy volunteers (HV) followed for 16-weeks.
Self-organization from organs to embryoids by activin in early amphibian development.
Cells Dev
January 2025
Department of Agri-Production Sciences, College of Agriculture, Tamagawa University, Tokyo, Japan.
Embryonic development is a complex self-organizing process orchestrated by a series of regulatory events at the molecular and cellular levels, resulting in the formation of a fully functional organism. This review focuses on activin protein as a mesoderm-inducing factor and the self-organizing properties it confers. Activin has been detected in both unfertilized eggs and embryos, suggesting its involvement in early developmental processes.
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