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| http://dx.doi.org/10.1152/ajplegacy.1965.208.6.1191 | DOI Listing |
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Impact of the probiotic on loperamide-induced delayed bowel movement in Sprague-Dawley rats.
Food Funct
January 2025
Institute of Human Behavior & Genetics, Korea University, Seoul 02841, Republic of Korea.
This study investigated the effects of on alleviating loperamide-induced constipation. To evaluate the efficacy of in Sprague-Dawley (SD) rats, fecal parameters, the intestinal transit rate, and changes in intestinal mucosal cells were measured through histological analysis. Additionally, serotonin levels, water absorption, tight junction-related gene expression, and the cecal short-chain fatty acid (SCFA) content were analyzed.
View Article and Find Full Text PDFAstragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice.
J Nanobiotechnology
December 2024
Beijing Key Laboratory of TCM Pharmacology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Background: Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manifestation of sleep disorder, can lead to energy metabolism disturbances, weakened immune system, and compromised body functions. In extreme situations, sleep deprivation can cause organ failure, presenting significant risks to human health.
View Article and Find Full Text PDFRenshen (Radix Ginseng) polysaccharide promotes repair of the mice intestinal mucosa through regulatory mechanisms based on polyamine and human antigen R.
J Tradit Chin Med
December 2024
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Objective: To investigate the mechanism and effect of Renshen () polysaccharide on the migration of intestinal epithelial cell line 6 (IEC-6), as well as the repair mechanism of Renshen () polysaccharide on colonic injury induced by dextran sulfate sodium (DSS) in mice.
Methods: Mice were fed 3% (w/v) DSS for 6 d to create colonic lesions. A cell-migration model was created using cell scratching.
Effects of Sub-Anesthetic Oro-Mucosal Dexmedetomidine on Sleep in Humans: A Randomized, Controlled Pharmacokinetics-Pharmacodynamics Study.
Anesthesiology
November 2024
Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland.
Article Synopsis
- The study investigates the use of dexmedetomidine, a selective α2 noradrenergic agonist, as a potential treatment for insomnia, especially in patients dealing with heightened distress, through new oro-mucosal delivery methods.
- Two formulations (sublingual and buccal) were tested in a pilot and main study involving both good and poor sleepers, focusing on pharmacokinetic and pharmacodynamic profiles alongside a range of sleep assessments.
- Results showed that buccal dexmedetomidine was quickly absorbed and effectively reduced sleep latency and increased NREM sleep duration in poor sleepers, while not significantly affecting cortisol or heart rate levels.
Clinical and radiographic assessment of the association between orthodontic mini-screws and periodontal health.
BMC Oral Health
November 2024
Department of Periodontology, Faculty of Dentistry, Dokuz Eylul University, Izmir, Türkiye.
Objectives: Proper anchorage control is crucial for predictable tooth movement and preventing inadequate torque during orthodontic treatment. Through clinical and radiographic parameters; this study assesses the association between mini-screws and periodontal health.
Materials And Methods: A prospective observational study included 16 systemically healthy non-smoking individuals requiring mini-screws.
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