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Ammonia-induced stress response in liver disease progression and hepatic encephalopathy.
Nat Rev Gastroenterol Hepatol
November 2024
UCM Digestive Diseases, Virgen del Rocío University Hospital. Instituto de Biomedicina de Sevilla (HUVR/CSIC/US), Department of Medicine, University of Seville, Seville, Spain.
Article Synopsis
- * Hyperammonaemia is a key feature of hepatic encephalopathy and is linked to poor outcomes in patients with liver conditions like cirrhosis and liver failure.
- * The review highlights how ammonia impacts liver diseases, the significance of ammonia measurement for diagnosing conditions like hepatic encephalopathy, and the potential for new treatments based on our understanding of ammonia metabolism.
Tolerance Factor Approach for the Design of Quaternary Materials as Applied to the ALnCuQ Homologous Series.
J Am Chem Soc
September 2024
Institute for Quantum Matter, William H. Miller III Department of Physics and Astronomy, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States of America.
The design of novel quaternary materials can be a chemically challenging endeavor. Here, we show that a new tolerance factor, we herein call the quaternary tolerance factor (QTF), akin to the Goldschmidt ratio, can be applied to a homologous series of quaternary materials to aid in the prediction of structural stability in new phases. Single crystals of nine new members of the CuQ homologous series were synthesized ( = K, Rb, Cs, = Sm, Gd, Tb, Dy, Er, Yb, Lu, = S, Se) for = 1, 2, and 3 using a reactive KCl flux method as the sole potassium source.
View Article and Find Full Text PDFThe Prevalence of Obstructive Sleep Apnea in Patients With Primary Aldosteronism.
J Clin Endocrinol Metab
September 2024
Department of Urology, National Taiwan University Hospital, Taipei 100225, Taiwan.
Context: Investigating the co-occurrence of obstructive sleep apnea (OSA) and primary aldosteronism (PA) is crucial for understanding their interrelation.
Objective: This work aimed to evaluate the prevalence of OSA in individuals diagnosed with PA and to assess the prevalence of PA within the OSA population, with a specific focus on hypertensive individuals.
Methods: An exhaustive search was performed across PubMed, Embase, CINAHL, Scopus, and Web of Science up to September 2023, without restrictions on language or publication date.
Association between admission serum potassium concentration and the island sign on cranial CT in HICH patients: a cross-sectional study.
Front Neurol
June 2024
Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
Objective: This study aimed to explore the correlation between serum potassium (K) concentration upon admission and the presence of the Island Sign (IS) in cranial CT scans of patients diagnosed with Hypertensive Intracerebral Hemorrhage (HICH), including the potential presence of a non-linear relationship.
Methods: This investigation constituted a single-center cross-sectional study. We systematically gathered comprehensive general clinical characteristics, biological indicators, and imaging data from a cohort of 330 patients diagnosed with HICH.
Nutrigenomics: SNPs correlated to minerals' deficiencies.
Clin Ter
November 2023
MAGI'S LAB, Rovereto (TN), Italy.
Nutrigenetics and nutrigenomics are two interrelated fields that explore the influence of genetic diversity on nutrient responses and function. While nutrigenetics investigates the effects of hereditary ge-netic variations on micronutrient metabolism, nutrigenomics examines the intricate relationship between diet and the genome, studying how genetic variants impact nutrient intake and gene expression. These disciplines offer valuable insights into predicting and managing chronic diseases through personalized nutritional approaches.
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