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The RNA-binding protein HuR impairs adipose tissue anabolism in pancreatic cancer cachexia.
bioRxiv
December 2024
Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR.
Background: Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC), and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear. This work aims to define the relative contributions of catabolism and anabolism to adipose wasting in PDAC-bearing mice.
View Article and Find Full Text PDFCold-active lipase from Psychrobacter alimentarius ILMKVIT and its application in selective enrichment of ω-3 polyunsaturated fatty acids in flax seed oil.
Bioprocess Biosyst Eng
December 2024
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Lipases are one of the ubiquitous enzymes that belong to the hydrolases family and have a wide variety of applications. Cold-active lipases are of major attraction as they can act in lower temperatures and low water conditions because of their inherent greater flexibility. One of the novel applications of lipase is the enrichment of ω-3 polyunsaturated fatty acids (PUFA) in plant and fish oils.
View Article and Find Full Text PDFThe repression of the lipolytic inhibitor G0s2 enhancers affects lipid metabolism.
Gene
February 2025
State Key Laboratory of Swine and Poultry Breeding Industry, Sichuan Agricultural University, Chengdu 611130, China; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; Chongqing Academy of Animal Sciences, Chongqing 402460, China; National Center of Technology Innovation for Pigs, Chongqing 402460, China. Electronic address:
Article Synopsis
- G0s2 is an inhibitor of adipose triglyceride lipase (ATGL), influencing triglyceride mobilization in fat and liver cells, and is linked to metabolic disorders like obesity and NAFLD.
- Researchers discovered three active enhancers of the G0s2 gene in adipocytes, which play a crucial role in its expression and lipid droplet formation.
- Further analyses showed that specific transcription factors, particularly PPARG and RXRA, regulate one of these enhancers (G0S2-En5), impacting pathways related to lipid metabolism.
Lipid Metabolism as a Target Site in Pest Control.
Adv Exp Med Biol
October 2024
Bayer AG, Crop Science Division, Monheim, Germany.
Lipid metabolism is essential to insect life as insects use lipids for their development, reproduction, flight, diapause, and a wide range of other functions. The central organ for insect lipid metabolism is the fat body, which is analogous to mammalian adipose tissue and liver, albeit less structured. Various other systems including the midgut, brain, and neural organs also contribute functionally to insect lipid metabolism.
View Article and Find Full Text PDFWithanolides-enriched leaf extract of Withania somnifera exert anti-obesity effects by inducing brown adipocyte-like phenotype via tuning MAP-kinase signaling axis.
Int J Biol Macromol
December 2024
Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India; Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Roorkee-Haridwar Road, Haridwar 249405, Uttarakhand, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address:
Present study investigated anti-obesity potential of Withania somnifera (L.) Dunal leaf extract (WSLE). Phytochemical characterization of WSLE was performed by UPLC/MS-QToF and HPLC-based analysis.
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