Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Advancing treatment strategies against MRSA: unveiling the potency of tubuloside A in targeting sortase A and mitigating pathogenicity.
World J Microbiol Biotechnol
January 2025
Clinical Medical College, Changchun University of Chinese Medicine, Changchun, China.
In addressing the formidable challenge posed by methicillin-resistant Staphylococcus aureus (MRSA), this investigation elucidates a novel therapeutic paradigm by specifically targeting the virulence factor sortase A (SrtA) utilizing Tubuloside A (TnA). SrtA plays a critical role in the pathogenicity of MRSA, primarily by anchoring surface proteins to the bacterial cell wall, which is crucial for the bacterium's ability to colonize and infect host tissues. By inhibiting SrtA, TnA offers a novel and distinct strategy compared to traditional antibiotics.
View Article and Find Full Text PDFNovel inhibition of sortase A by plantamajoside: implications for controlling multidrug-resistant infections.
Appl Environ Microbiol
December 2024
Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Article Synopsis
- The research introduces plantamajoside (PMS) as an innovative inhibitor of sortase A (SrtA), an enzyme crucial for the virulence of methicillin-resistant Staphylococcus aureus (MRSA), showcasing its potential in combating multi-drug resistant pathogens.
- PMS effectively reduces MRSA's ability to adhere to surfaces and form biofilms, leading to increased survival rates in infected cell models and proving beneficial in animal models by lowering mortality rates and bacterial loads.
- The findings emphasize the significance of targeting specific bacterial mechanisms, such as SrtA, to develop new therapeutic strategies against antibiotic-resistant infections, particularly MRSA.
Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin (STOP-Vanc): study protocol for a randomized controlled trial.
Trials
December 2024
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA is rarely implicated in CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify the presence of MRSA colonization has been proposed as an antimicrobial stewardship intervention to reduce the use of vancomycin. Observational studies have shown reductions in vancomycin use after implementation of MRSA colonization testing, and this approach has been adopted by CAP guidelines.
View Article and Find Full Text PDFPrimary Staphylococcal Lung Abscess: A Rare Situation in Infants.
Cureus
November 2024
Pediatric Surgery, Mohammed VI University Hospital, Oujda, MAR.
Primary pulmonary abscess is a rare but serious localized bacterial infection of the lung parenchyma, occurring without prior lung conditions like bronchiectasis or necrotizing pneumonia. We report the case of an 11-month-old child with a 22-day history of productive cough and fever, unresponsive to initial antibiotics. Clinical examination showed a stable, eupneic child with mild fever and reduced oxygen saturation.
View Article and Find Full Text PDFCommunity-Acquired Pneumonia in Adults: A Mono-Center Retrospective Study.
Tanaffos
January 2024
Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- Adult community-acquired pneumonia is a major health issue, leading to hospitalizations and deaths. A study looked at adult patients hospitalized due to pneumonia during the cold seasons of 2018 and 2019, identifying various microorganisms responsible for the infections.
- Of 205 patients, 57% had identifiable microorganisms, with Influenza H1N1 2009 being the most common, followed by Tuberculosis, non-albicans Candida, and methicillin-resistant Staphylococcus Epidermidis, with pneumonia cases showing a concerning mortality trend associated with staphylococcal infections.
- The findings emphasize the need for prompt, specific treatment protocols for staphylococcal pneumonia and highlight the necessity of considering both community-acquired
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!