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The Composition and Biochemical Properties of Strophantus (Apocynaceae), with a Focus on .
Molecules
June 2024
Core Unit Proteomics, Interdisciplinary Center for Clinical Research, University of Münster, 48149 Münster, Germany.
The genus Strophantus belongs to the Apocynaceae family of flowering plants which grows primarily in tropical Africa. The plants are widely used in traditional herbal medicine. , in particular, is used for the treatment of, e.
View Article and Find Full Text PDFCardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome.
Biochem Biophys Res Commun
October 2021
Department of Anatomy and Embryology, Leiden University Medical Center (LUMC), 2333, ZA, Leiden, the Netherlands; Department of Biology, University of Padua, 35121, Padua, Italy; Veneto Institute of Molecular Medicine, 35129, Padua, Italy. Electronic address:
Background: Human induced pluripotent stem cells (hiPSCs) and their derivative cardiomyocytes (hiPSC-CMs) have been successfully used to study the electrical phenotype of cardiac ion channel diseases. However, strategies to mature CMs and more comprehensive systems recapitulating the heart complexity are required to advance our ability to capture adult phenotypes.
Methods: We differentiated wild-type (WT) and long QT syndrome type 1 (LQT1) hiPSCs into CMs, endothelial cells and cardiac fibroblasts.
FMRFamide-Related Peptides Signaling Is Involved in the Regulation of Muscle Contractions in Two Tenebrionid Beetles.
Front Physiol
May 2020
Department of Animal Physiology and Development, Adam Mickiewicz University, Poznań, Poland.
Peptidergic signaling regulates various physiological processes in insects. Neuropeptides are important messenger molecules that act as neurotransmitters, neuromodulators or hormones. Neuropeptides with myotropic properties in insects are known as FMRFamide-like peptides (FaLPs).
View Article and Find Full Text PDFSynthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities.
Med Chem
June 2021
Pharmacology Department, National Research Centre, Dokki, Giza 12622, Egypt.
Background: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction, and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency.
Objectives: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity.
Methods: A new series of synthesized compounds were carried out first by the synthesis of 6- flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic acid with hydrazine hydrate or arylhydrazines to provide the corresponding pyridazinone derivatives 2a-d.
Exploring cardiac plasticity in teleost: the role of humoral modulation.
Gen Comp Endocrinol
November 2019
Dept of Biology, Ecology and Earth Sciences (BEST), University of Calabria, 87030, Arcavacata di Rende, CS, Italy.
The fish heart represents an established natural model for evaluating basic mechanisms of the coordinated physiological reactions which maintain cardiac steady-state. This is due to its relatively simple design, but also to its multilevel morpho-functional flexibility which allows adequate responses to a variety of intrinsic (body size and shape, swimming performance, etc.), and extrinsic (temperature, salinity, oxygen level, water chemistry, etc.
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