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Arthritis in patients with chronic hepatitis C virus infection.

J Rheumatol

February 1999

Instituto Provincial de Rehabilitación, Internal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Objective: To describe the clinical picture of arthritis in patients with chronic infection by hepatitis C virus (HCV).

Methods: Two patient populations were studied. Patients with arthritis and evidence of serum elevation of alanine aminotransferase (ALT) at the consultation were checked for HCV infection.

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Deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the yellow ligament occasionally leads to neurological deficits through compression of the spinal cord. Although it is widely accepted that CPPD crystal induces severe inflammation in arthropathy, little attention has been paid to the acute inflammation that may accompany the CPPD crystals in the ligamentum flavum. The present study reviews eight patients with radiculomyelopathy due to calcification of the cervical yellow ligament.

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Two cases of tuberculous arthritis in a joint affected with chondrocalcinosis are reported. No similar cases have been published. Diagnosis was established by demonstration of the tubercle bacillus and calcium pyrophosphate crystals in the joint fluid.

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Arthroscopy and chondrocalcinosis.

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April 1992

Institution for Pathology, Trade Co-Operative Hospitals, University Clinic, Bergmannsheil Bochum, F.R.G.

Different pathogenetic factors have been associated with the development of chondrocalcinosis. Under normal conditions, previous degenerative meniscus changes with proliferation of "pseudochondrocytes" and chondrocalcinosis have been found coincidentally. Small fragments can be excised during arthroscopy for histological assessment of the developmental stages and localization of chondrocalcinosis.

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Knee joint radiographs from 45 patients with articular chondrocalcinosis (CC), 23 with osteoarthrosis (OA) and 19 with rheumatoid arthritis (RA) were compared. The incidence of conventional radiographic features of osteoarthrosis, osteophytes, joint space narrowing subchondral cysts, subchondral sclerosis, and varus or valgus deformity was equal in CC and OA joints. But distinctive changes in the patello-femoral area were found in half of the CC joints.

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