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Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Keratinization.
Dermatopathology (Basel)
July 2018
Department of Diagnostic Pathology, Suwa Red Cross Hospital, Suwa, Japan.
Shadow cells are characterized by an eosinophilic cytoplasm and a ghost-like nuclear contour; the cell shape is preserved, in spite of nuclear disappearance. Shadow cell nests (SCNs) are frequently observed in pilomatricoma (PMX), where the transitional cells immediately adjacent to SCNs often have a crescent-shaped nucleus showing fragmentation similar to that of apoptotic bodies. They show nuclear accumulation of beta-catenin and DNA double strand breaks (as revealed by in situ 3'-tailing reaction or immunohistochemistry for single-stranded DNA [ssDNA]), while they are negative for cleaved caspase-3 or cleaved lamin A, suggesting that shadow cell differentiation (SCD) is a caspase-independent programmed cell death.
View Article and Find Full Text PDFShadow cell differentiation from squamoid morule in endometrial adenoacanthoma.
Int J Clin Exp Pathol
October 2016
Department of Pathology, Suwa Red Cross Hospital Suwa 392-8510, Japan.
Shadow cell differentiation (SCD), commonly found in cutaneous pilomatricoma (PMX), has been said to be extremely rare in extracutaneous tumors and its morphogenesis has not been clarified yet. In the present study, 25 cases of endometrial adenoacanthoma were examined with special reference to SCD and with immunohistochemistry for beta-catenin and CD10. Shadow cell nests (SCNs) were observed in 2 out of 5 cases of adenocarcinoma with squamoid morules and all of 4 cases of adenocarcinoma with squamous differentiation and morules, but not in any cases of adenocarcinoma with squamous differentiation.
View Article and Find Full Text PDFFirst report of an endometrial adenoacanthoma in a dog.
Acta Vet Hung
June 2011
Szent István University Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science István utca 2 H-1078 Budapest Hungary.
Uterine adenoacanthoma, a subtype of primary endometrial adenocarcinoma, was found in a tissue specimen removed during ovariohysterectomy from an 8-year-old German Shepherd dog. Multifocal, benign squamous metaplastic islands were identified in the parenchyma of the malignant endometrial tumour. The tumour was highly infiltrative but did not metastasise to other organs.
View Article and Find Full Text PDFVEGF and its receptors (flt-1 and KDR/flk-1) as prognostic indicators in endometrial carcinoma.
Tumour Biol
June 2005
Department of Obstetrics and Gynaecology, University of Oulu, Oulu, Finland.
Vascular endothelial growth factor (VEGF) is associated with increased angiogenesis and aggressive tumour growth. We investigated the expression and clinical significance of VEGF and its receptors, flt-1 and KDR/flk-1, in patients with uterine endometrial carcinoma. The series consisted of 115 endometrioid endometrial adenocarcinoma patients with FIGO stage I-IV.
View Article and Find Full Text PDF[The role of biomarkers CK7, Vim and P53 in the development of subtypes of endometrial carcinoma].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2005
The Obstetrics & Gynecology Hospital, Medical Center of Fudan University, Shanghai 200011, China.
Objective: Analyzing the protein expression of biomarkers CK7, Vim, and P53 to investigate their possible pathogenic roles in the development of variant subtypes of endometrial carcinoma.
Methods: Biomarkers CK7, Vim, and P53 were immunohistochemistry-stained among 131 endometrial carcinoma specimens including 93 endometroid, 8 adenoacanthoma, and 32 rare subtypes of adenosquamas carcinoma, clean cell carcinoma, and papillary carcinoma, which had been confirmed clinically and pathologically, and studied statistically with Fisher test and Cochran-Mantel-Haenszel (CMH) Test.
Results: Positive correlation was demonstrated among CK7, Vim, and P53 expression levels.
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