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Efficacy of Aster chinensis aerial parts metabolites in BALB/c mice model of Imiquimod-induced psoriasis skin inflammation.
Inflammopharmacology
March 2025
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Using a bioassay-guided fractionation approach, the most potent anti-psoriatic components of Aster squamatus herb, Aster chinensis stalks, and Aster chinensis flowers, cultivated in Egypt, were identified and evaluated against Imiquimod (IMQ)-induced psoriasis in female BALB/c mice and compared to standard drug, mometasone. The topical application of A. chinensis stalk methanolic extract exhibited the strongest anti-psoriatic effects against IMQ-induced psoriasis model, as evidenced by improvements in psoriasis area severity index (PASI) score, histopathological analysis, and spleen index.
View Article and Find Full Text PDFAnti-inflammatory Effect of Microwave-Assisted Extract (MA-OHE) against DSS-Induced Colitis.
ACS Appl Bio Mater
March 2025
Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Republic of Korea.
Ulcerative colitis (UC), including chronic colitis, is characterized by severe inflammation and oxidative stress in the colon. This study investigated the therapeutic potential of microwave-assisted extract (MA-OHE), prepared using water (WE) and water-methanol (WME) solvents, in a chronic colitis model in mice induced by dextran sodium sulfate (DSS). Chemical profiling using UV-vis, FTIR, and HPLC analyses revealed that WME contains significantly higher concentrations of phenolic and flavonoid compounds than WE.
View Article and Find Full Text PDFAntioxidant and Anticancer Activity of Tamarix Indica Aerial Extracts against DMBA/croton Oil-Induced Skin Carcinogenesis in Mice.
Asian Pac J Cancer Prev
February 2025
Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP) India.
Background: The largest organ, skin, acts as the body's first line of protection against various environmental threats and harmful substances, which may be carcinogenic. The widespread acceptance of conventional chemotherapy has been hindered by its high cost and severe side effects, which have encouraged the need for alternatives. The phytoconstituents produced by plants promise to prevent skin carcinogenesis by targeting multiple steps.
View Article and Find Full Text PDFQuantification of three neurotransmitters in cerebrospinal fluid, serum and random urine using a robust and simplified liquid chromatography-tandem mass spectrometry method.
J Chromatogr A
April 2025
Department of Laboratory Medicine; Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:
Imbalance in the monoamine neurotransmitters has been implicated in a variety of neurological disorders, making it necessary to quantify neurotransmitters accurately. Thus, the study aims to develop a robust and validated method for simultaneously quantifying serotonin, 5-Hydroxyindole Acetic Acid (5-HIAA), and homovanillic acid (HVA) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). One-step precipitation with methanol containing 0.
View Article and Find Full Text PDFUnravelling the prophylactic anti-inflammatory potential of Koenigia tortuosa through modulation of cytokine levels and inflammatory markers in LPS-induced localized inflammation in Wistar rat models.
Inflammopharmacology
February 2025
Department of Clinical Biochemistry/Biochemistry, University of Kashmir Hazratbal, Srinagar, 190006, Jammu and Kashmir, India.
Chronic inflammation, a pivotal factor in various chronic diseases, necessitates safe and effective treatments to alleviate disease severity and symptoms. Current interventional approaches, including synthetic steroids and non-steroidal anti-inflammatory drugs, pose safety concerns. Consequently, people seek plant-based alternatives as safer substitutes.
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