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Comparative 3D ultrastructure of Plasmodium falciparum gametocytes.
Nat Commun
January 2025
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Despite the enormous significance of malaria parasites for global health, some basic features of their ultrastructure remain obscure. Here, we apply high-resolution volumetric electron microscopy to examine and compare the ultrastructure of the transmissible male and female sexual blood stages of Plasmodium falciparum as well as the more intensively studied asexual blood stages revisiting previously described phenomena in 3D. In doing so, we challenge the widely accepted notion of a single mitochondrion by demonstrating the presence of multiple mitochondria in gametocytes.
View Article and Find Full Text PDFDevelopment and validation of a novel tool to measure tear volume in volumetric unit (microlitre) per minute "the standard international unit (SI) tear strip".
Indian J Ophthalmol
January 2025
Department of Pharmacology, All India Institute of Medical Sciences, Guwahati, Assam, India.
The Schirmer strip measures tear volume in millimeters. A major limitation of the Schirmer strip is that it does not measure tear volume in a volumetric unit. Furthermore, the linearity range, lower limit of detection (LLOD), and lower limit of quantification (LLOQ) are not established.
View Article and Find Full Text PDFIntegration of Immunosyringe Sensors with Bar-Chart Chips for Prick-and-Read Testing of Prostate Specific Antigen.
Anal Chem
December 2024
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong 264005, China.
Pressure-based signal transduction is of promise in developing microfluidic immunoassays such as volumetric bar-chart chips (V-chips), but new working principles are required to further simplify the methods in point-of-care testing (POCT). Herein, we developed immunosyringe sensors and integrated them with bar-chart chips for simple prick-and-read testing of prostate specific antigen (PSA) as a model target. Disposable syringes served as the host for the construction of the sandwich-type immuno-recognition system.
View Article and Find Full Text PDFPerformance study of oil-injection hermetic CO2 scroll compressor for automotive air conditioning system.
PLoS One
December 2024
National Engineering Research Center of Fluid Machinery and Compressors, Xi'an Jiaotong University, Xi'an, P. R. China.
An oil-injection CO2 scroll compressor prototype and relative simulation model are developed for automotive Air Conditioning. The effects of oil to refrigerant mass ratio on the compressor performance are studied theoretically and experimentally. The results show that oil-injection is an effective way to improve the volumetric and indicated efficiencies, and reduce discharge temperature.
View Article and Find Full Text PDFThree-dimensional digital imaging analysis of the palatal bone thickness for orthodontic mini-implant insertion - determination of the safe zone and angulation.
BMC Oral Health
November 2024
Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Erlangen of Friedrich-Alexander University Erlangen-Nürnberg (FAU), Glückstraße 11, 91054, Erlangen, Germany.
Background: In order to successfully perform orthodontic mini-implant procedures successfully for the subsequent anchoring of orthodontic appliances, it is crucial to know the palatal bone thickness. This is usually assessed using two-dimensional radiographs. The purpose of this study was to use a three-dimensional digital imaging measurement method to provide information on palatal bone volume and bone thickness and to make recommendations on the optimal and safe insertion site and angle for palatal mini-implants.
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