AI Article Synopsis
- Microcin 25 is a peptide antibiotic produced by a strain of Escherichia coli found in human feces, consisting of approximately 20 amino acids and having a blocked amino-terminal end.
- Its synthesis and the bacteria's immunity to it are controlled by plasmids, and it is produced during the stationary phase of bacterial growth in minimal medium.
- The antibiotic disrupts cell division, causing susceptible bacteria to filament, but this effect does not appear to be linked to the SOS response system.
Article Abstract
Microcin 25, a peptide antibiotic excreted by an Escherichia coli strain isolated from human feces, was purified to homogeneity and characterized. Composition analysis and data from gel filtration indicated that microcin 25 may contain 20 amino acid residues. It has a blocked amino-terminal end. Microcin synthesis and immunity are plasmid determined, and the antibiotic was produced in minimal medium when the cultures entered the stationary phase of growth. The peptide appears to interfere with cell division, since susceptible cells filamented when exposed to it. This response does not seem to be mediated by the SOS system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC207439 | PMC |
| http://dx.doi.org/10.1128/jb.174.22.7428-7435.1992 | DOI Listing |
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