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Melatonin secretion across puberty: A systematic review and meta-analysis.
Psychoneuroendocrinology
January 2025
Danish Center for Sleep Medicine, Rigshospitalet, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Background: Melatonin levels decrease with aging and substantially during puberty. Studies have presented distinct melatonin levels in patients with disorders related to their pubertal development compared to healthy controls. The discrepancy suggests that a decrease in melatonin concentrations seen during adolescence might be related to the physical, hormonal, and/or neuronal alterations that occur during the pubertal period.
View Article and Find Full Text PDFWhat are the challenges that social prescribers face when supporting people within dementia and how can these be addressed? A qualitative study.
PLoS One
January 2025
Research Department of Primary Care & Population Health, Centre for Ageing Population Studies, University College London, London, United Kingdom.
Introduction: Evidence suggests that social prescribing might have a positive impact on identity, control, creativity and quality of life in people with dementia. While evidence on the benefits of social prescribing is accumulating, there is a sparsity of research on the experiences of social prescribers. This study aims to identify the challenges that social prescribers face when supporting people with dementia and their families and strategies to address these.
View Article and Find Full Text PDFMeasuring Talker Age Estimates Through Crowdsourced Listeners' Ratings: A Pilot Study for Voice Research.
J Speech Lang Hear Res
January 2025
Department of Otolaryngology-Head and Neck Surgery, New York University Grossman School of Medicine, NY.
Purpose: Most auditory-perceptual voice research utilizes the judgments of trained listeners rather than everyday listeners with no previous training in speech pathology. Online crowdsourcing of behavioral data from untrained participants is rapidly increasing in popularity but has yet to be a common procedure for auditory-perceptual studies of the voice. The objective of this pilot study was to assess the functionality of this model for judgments of voice by using an online experiment platform to replicate a lab-based, voice-specific age estimation study.
View Article and Find Full Text PDFPreliminary comparison of net gain in final adult height of girls with early menarche treated with or without gonadotropin-releasing hormone agonist.
Transl Pediatr
December 2024
Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China.
Background: Early menarche is associated with both physical and psychosocial problems. Based on psychological and physical health considerations, for girls with early menarche, some parents and physicians may elect to use gonadotropin-releasing hormone agonists (GnRHa) to delay menstruation. This study aimed to explore the effects of GnRHa treatment on the final height of girls with early menarche and build the models to predict the final adult height (FAH).
View Article and Find Full Text PDFExploring the anti-aging potential of natural products and plant extracts in budding yeast : A review.
F1000Res
January 2025
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS).
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