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Preparation and Characterization of a Novel Magnetic Molecularly Imprinted Polymer Capable of Isolating and Purifying Cordycepin from a Submerged Culture of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes).
Int J Med Mushrooms
December 2024
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China; Shandong Provincial Collaborative Innovation Center for Quality Control and Construction of the Whole Industrial Chain of Traditional Chinese Medicine, Jinan, Shandong, 250355, People's Republic of China.
In this work, magnetic molecularly imprinted polymer (MMIP) capable of selectively recognizing and adsorbing cordycepin was prepared. The MMIP was prepared using cordycepin as the template molecule, methacrylic acid and acrylamide as the functional monomer and ethylene glycol dimethacrylate as the crosslinker. The MMIP was analyzed using various techniques including transmission electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometer and x-ray diffraction.
View Article and Find Full Text PDFCordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.
J Ethnopharmacol
January 2025
School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, the People's Republic of China. Electronic address:
Ethnopharmacological Relevance: Cordycepin, the main active component of Cordyceps militaris, exhibits various pharmacological activities, including anti-tumor and antioxidant effects. However, its antidepressant effect and the underlying mechanisms remain unclear.
Aim Of Review: This study aimed to explore the antidepressant effect of cordycepin and elucidate the potential molecular mechanisms.
Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro.
Reprod Biol Endocrinol
November 2024
School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte. Cordycepin, a bioactive compound first isolated from Cordyceps militaris, is an adenosine analog with numerous physiological activities.
View Article and Find Full Text PDFInsights into the methods for separation and chromatographic determination of nucleotides/nucleosides in Cordyceps spp.
J Chromatogr A
October 2024
The Ministry of Education Key Laboratory of Standardization of Chinese Medicine, Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China, Resources Breeding Base of Co-Founded, College of Pharmacy, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, China. Electronic address:
Cordyceps genus is entomopathogenic mushrooms that have traditionally been used in ethnomedicine in Asian countries. Nucleosides (Ns), nucleotide(Nt), Nucleobases (Nb) and their analogues play a critically physiological role and have a great potential in drug development, such as pentostatin and cordycepin (COR). Due to their significance bioactivity, several Nt/Ns were used as markers for quality evaluation for medicinal Cordyceps, including adenosine, inosine, guanosine, uridine and COR.
View Article and Find Full Text PDFThe role and mechanisms of cordycepin in inhibiting cancer cells.
Braz J Med Biol Res
August 2024
School of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
With the escalating incidence and mortality rates of cancer, there is an ever-growing emphasis on the research of anticancer drugs. Cordycepin, the primary nucleoside antibiotic isolated from Cordyceps militaris, has emerged as a remarkable agent for cancer prevention and treatment. Functioning as a natural targeted antitumor drug, cordycepin assumes an increasingly pivotal role in cancer therapy.
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