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Development of a Patient Reported Outcome Measure of Side Effects for Patients Taking Calcineurin Inhibitors: The FACIT-CNI-Ntx.
Am J Kidney Dis
January 2025
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA; Northwestern University Transplant Outcomes Research Collaborative, Comprehensive Transplant Center, Feinberg School of Medicine, Chicago, IL, USA; Centre for Patient Reported Outcomes Research, Department of Applied Health Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Rationale & Objective: Valid measures of side effects are important to inform clinical use of calcineurin inhibitors (CNIs). This study sought to develop and establish the content validity of a PRO measure to capture side effects among kidney transplant recipients taking CNIs.
Study Design: Qualitative interviews for concept elicitation and cognitive debriefing.
Brain connectivity, neural networks, and resilience in aging and neurodegeneration.
Am J Pathol
January 2025
Center for the Neural Basis of Cognition; Department of Pathology; Department of Bioengineering; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
The importance of complex systems has become increasingly evident in recent years. The nervous system is one such example with neural networks sitting at the intersection of complex networks and biology. A particularly exciting feature is the resilience of complex systems.
View Article and Find Full Text PDFAttributes novel drug candidate: Constitutive GPCR signal bias mediated by purinergic receptors.
Pharmacol Ther
January 2025
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China; School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China.
G protein-coupled receptors (GPCRs) can transmit signals via G protein-dependent or independent pathways due to the conformational changes of receptors and ligands, which is called biased signaling. This concept posits that ligands can selectively activate a specific signaling pathway after receptor activation, facilitating downstream signaling along a preferred pathway. Biased agonism enables the development of ligands that prioritize therapeutic signaling pathways while mitigating on-target undesired effects.
View Article and Find Full Text PDFWashed microbiota transplantation effectively improves nutritional status in gastrointestinal disease-related malnourished children.
Nutrition
January 2025
Department of Microbiota Medicine & Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China; Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, China. Electronic address:
Background And Aim: Gut microbiota dysbiosis plays a critical role in malnutrition caused by food intolerance and intestinal inflammation in children, which needs to be addressed. We assessed the efficacy and safety of washed microbiota transplantation (WMT) for gastrointestinal disease-related malnourished children.
Methods: This was a prospective observational study involving gastrointestinal disease-related malnourished pediatric patients who underwent WMT.
Life cycle assessment and industrial synergy for carbon reduction: A circular economy approach.
Sci Total Environ
January 2025
Geology and Sustainable Mining Institute, Mohammed VI Polytechnic University, Lot 660, Hay Moulay Rachid, Ben Guerir 43150, Morocco.
In the face of the climate change crisis, circular economy (CE) is put forward as a promising key to the sustainable development goals (SDGs) riddle. In this context that affects developed and developing countries alike, circular initiatives arise, such is the case for Morocco where an industrial synergy based on the CE concept of 'waste is food' can be envisioned between the local phosphate and cement industries. In order to support and guide this initiative, a life cycle assessment (LCA) was conducted to compare the environmental performance of the production of ordinary Portland cement (OPC), limestone calcined clay cement (LC3) and a phosphate waste-based cement known as calcined marl cement (CMC).
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