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Anesth Analg
January 2009
Division of Pulmonary Medicine, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Background: Acute interstitial pneumonia is a rapidly progressive disease frequently leading to respiratory failure and mechanical ventilation. The prognosis is usually poor despite aggressive diagnostic and treatment efforts.
Methods: In this retrospective cohort survey, we enrolled patients with hypoxemic respiratory failure who met predefined criteria of acute idiopathic interstitial pneumonia.
Following a brief mention of the classification of Hammer-Rich disease within idiopathic diffuse pulmonary fibrosis, the main clinical, radiological and laboratory features of these disease are outlined in brief. A personal case, subsequently controlled neroptically and histologically, is then described. From comparison between reported data and findings in the personal case, it is concluded that it was a typical, rare case (less than 150 others have so far been reported in all world literature) of Hamman-Rich disease.
View Article and Find Full Text PDFAn observation of Hamman-Rich syndrome in a man of 47 with an acute, rapidly progressive course due to an immunoconflict situation in the lungs is presented. This situation is characterized by marked changes of the microcirculatory bed of interalveolar septae, with increased permeability, productive-desquamative alveolitis and formation of hyalin membranes, lymphoid-macrophage cell reaction of diffuse fibrosis. The peculiar features of this case include not only the involvement of the lungs but also the occurrence of generalized productive vasculitis with the involvement of the myocardium and the kidneys which, alongside with considerable immune alterations in the spleen and lymph nodes, confirm the hypothesis of the systemic autoaggression nature of this disease.
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