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Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia.
BMC Psychiatry
December 2024
Department of Psychiatry, Guangzhou Civil Affairs Bureau Psychiatric Hospital, Guangzhou, 510430, China.
Objective: Cognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors and the presence of antioxidants, which relationship is unclear. The study aimed to investigate cognitive function and its influencing factors in Chinese patients with SCZ.
Methods: A group of 133 patients with SCZ and 120 healthy controls (HCs) were recruited.
Glial Derived Neurotrophic Factor and Schizophrenia Spectrum Disorders: A Scoping Review.
Curr Neuropharmacol
December 2024
Ospedale San Luigi Gonzaga, Università degli Studi di Torino, Italia; Regione Gonzole, 10, Orbassano 10043, Torino, Italia.
Background: Psychotic disorders, characterized by altered brain function, significantly impair reality perception. The neurodevelopmental hypothesis suggests these disorders originate from early brain development disruptions. Glial-derived neurotrophic factor (GDNF) is crucial for neuronal survival and differentiation, especially in dopaminergic neurons, and shows promise in neurodegenerative and neuropsychiatric conditions.
View Article and Find Full Text PDFVariations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits.
BMC Psychiatry
November 2024
Department of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, No. 316, Jiefangdong Road, Lianyungang, Jiangsu, 222003, PR China.
Background: Immune dysregulation has been identified as a contributing factor in the pathophysiology of schizophrenia. This study aimed to investigate variations in specific immune regulators and their correlation with psychopathology and cognitive functions in male patients with chronic schizophrenia.
Methods: Employing a cross-sectional design, this study included 72 male patients with chronic schizophrenia.
Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence.
World J Psychiatry
September 2024
Department of General Affairs, Shaoxing Seventh People's Hospital, Shaoxing 312000, Zhejiang Province, China.
Background: Schizophrenic patients are prone to violence, frequent recurrence, and difficult to predict. Emotional and behavioral abnormalities during the onset of the disease, resulting in active myocardial enzyme spectrum.
Aim: To explored the expression level of myocardial enzymes in patients with schizophrenia and its predictive value in the occurrence of violence.
Toxoplasma gondii infection is associated with schizophrenia from the perspectives of seroepidemiology and serum metabolomics in Hunan Province, China.
Microb Pathog
October 2024
Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, 410013, Hunan, China. Electronic address:
Toxoplasma gondii (T.gondii) can influence the host's neurotransmission, central immune responses, and brain structure, potentially impacting the onset and development of various psychiatric disorders such as schizophrenia. We employed Electrochemiluminescence Immunoassay (ECLIA) to measure anti-Toxoplasma antibodies in 451 schizophrenic patients and 478 individuals from the general population in Hunan, China.
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