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The Effect of D-Tagatose on Fructose Absorption in a Rat Model.
J Dev Drugs
January 2013
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, USA.
D-tagatose is in development as a medication for the treatment of type 2 diabetes. The effect of oral D-tagatose on the absorption of D-fructose was assessed when co-administered in this study. In the pilot study, male Sprague-Dawley rats were fed C14 labeled fructose and glucose concomitantly to establish dose levels for the treatment group of rats fed C14 labeled fructose together with D-tagatose.
View Article and Find Full Text PDFThe transport of vitamin C in the isolated human near-term placenta.
Eur J Obstet Gynecol Reprod Biol
September 1995
Abteilung für experimentelle Medizin, Universitäts-Frauenklinik Eppendorf, Hamburg, Germany.
We investigated the specific uptake (reference: [H3]-L-glucose) as a measure of membrane transfer of [C14]-labeled L-ascorbic acid (AA), L-dehydroascorbic acid (DHA) and diketogulonic acid using the single injection, double tracer dilution method in the artificially perfused lobe of the near-term human placenta. The uptake of DHA (40-60%) on both the fetal and the maternal side was 3-6 times higher than the uptake of AA, whereas an uptake of diketogulonic acid was not detected. AA transport was slightly higher on the maternal side.
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