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Serum-biomarker-based population screening model for hepatocellular carcinoma.
iScience
March 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China.
Hepatocellular carcinoma (HCC) early identification is crucial for improving patient outcomes. Current screening methods are often complex and costly. This study developed a simplified, cost-effective HCC screening model using serum marker data.
View Article and Find Full Text PDFPerformance of Government-Financed Cervical Cancer Screening in Hunan, China and Optimization of Triage Strategies.
J Low Genit Tract Dis
February 2025
The Maternal and Child Health Hospital of Hunan Province, Changsha, China.
Objectives: Cervical cancer is a preventable and manageable public health concern. This study aimed to evaluate the performance of a government-financed cervical cancer screening program and to discuss optimal primary screening approach and triage strategies for large-scale population screening.
Methods: This population-based study was conducted from 2015 to 2020 and included 6,373,279 eligible women.
Preliminary establishment and evaluation of a rapid detection method for GII human norovirus based on time-resolved fluorescence chromatography.
Anal Methods
January 2025
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.
Article Synopsis
- Human norovirus leads globally in causing stomach infections across all ages.
- A new detection method using time-resolved fluorescence microsphere immunochromatography was developed, maximizing sensitivity and speed for identifying the VP1 protein of norovirus GII in only 15 minutes.
- The method displays high accuracy with a 96.60% overall coincidence rate in clinical samples, indicating its potential for quick and effective diagnostics in healthcare settings.
One-class classification with confound control for cognitive screening in older adults using gait, fingertapping, cognitive, and dual tasks.
Comput Methods Programs Biomed
February 2025
Faculty of Engineering, University of Porto, 4200-465, Porto, Portugal; INESC TEC (Institute for Systems and Computer Engineering, Technology and Science), 4200-465, Porto, Portugal. Electronic address:
Background And Objectives: Early detection of cognitive impairment is crucial for timely clinical interventions aimed at delaying progression to dementia. However, existing screening tools are not ideal for wide population screening. This study explores the potential of combining machine learning, specifically, one-class classification, with simpler and quicker motor-cognitive tasks to improve the early detection of cognitive impairment.
View Article and Find Full Text PDFIdentifying potentially undiagnosed individuals with hyper-IgE syndrome using a scoring system.
Ann Allergy Asthma Immunol
December 2024
School of Medicine, Tel Aviv University, Tel Aviv, Israel; Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel. Electronic address:
Background: Hyper-IgE syndrome (HIES) constitutes a group of rare primary immunodeficiency disorders. The diagnosis relies on the National Institutes of Health (NIH) scoring system, incorporating clinical and laboratory data. Scores greater than or equal to 15 raise a strong suspicion of the disease.
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