AI Article Synopsis
- The study aimed to evaluate the effectiveness of prophylactic antibiotics in preventing infections in patients with open and basilar skull fractures.
- A total of 157 patients were divided into three groups: no antibiotics, ceftriaxone, and ampicillin/sulphadiazine for three days each.
- Results showed that while the incidence of meningitis was similar across all groups, the non-antibiotic group had a significantly higher rate of overall infectious complications compared to the antibiotic groups, indicating the potential benefit of antibiotic prophylaxis.
Article Abstract
The aim of this study was to investigate the controversial issue of the use of prophylactic antibiotics in open and basilar fractures of the skull. A series of 157 patients were randomized to receive no antibiotics (group A = 46 patients) or ceftriaxone for 3 days (group B = 50 patients), or the combination ampicillin/sulphadiazine for 3 days (group C = 61 patients). The incidence of meningitis was similar in both the antibiotic and non-antibiotic groups. However, the overall incidence of infectious complications in the non-antibiotic group was significantly higher than in the antibiotic group (8.7 per cent vs 0.9 per cent, P < 0.05). There was no significant difference between the ceftriaxone group and the ampicillin/sulphadiazine group. The results of the study suggest that antibiotic prophylaxis has a role in the management of open and basilar fractures.
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| http://dx.doi.org/10.1016/0020-1383(92)90011-g | DOI Listing |
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