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Effects of hyperthermia and acidosis on mitochondrial oxidative phosphorylation.
J Appl Physiol (1985)
December 2024
Central Hospital for Veterinary Medicine, North Haven, Connecticut, United States.
The intracellular environment of skeletal muscle can develop pronounced hyperthermia and acidosis during strenuous exercise, and these alterations in the typical intracellular conditions have been shown to alter mitochondrial respiration. However, the impact of these conditions on ATP synthesis is poorly understood. We used Thoroughbred racehorses to test the hypothesis that both hyperthermia and acidosis decrease the rate of ATP synthesis, but that athletic conditioning mitigates this loss of phosphorylation capacity.
View Article and Find Full Text PDFSex differences in the effects of N-ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression.
Br J Pharmacol
November 2024
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.
Background And Purpose: New psychoactive substances such as N-ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study compares some key effects of NEP in male and female mice.
Experimental Approach: Psychostimulant, rewarding and reinforcing effects were investigated by tracking locomotor activity, conditioned place preference (CPP) paradigm and through a self-administration (SA) procedure, respectively, in CD1 mice.
Microglia Caspase11 non-canonical inflammasome drives fever.
Acta Physiol (Oxf)
September 2024
Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
Aim: Animals exhibit physiological changes designed to eliminate the perceived danger, provoking similar symptoms of fever. However, a high-grade fever indicates poor clinical outcomes. Caspase11 (Casp11) is involved in many inflammatory diseases.
View Article and Find Full Text PDFΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival.
J Pathol
July 2024
Department of Medicine, Faculty of Medicine, "Alberto Sols" Biomedical Research Institute, CSIC-UAM and IdiPAZ, Madrid, Spain.
Peritoneal metastasis of colorectal origin appears in ~10-15% of patients at the time of diagnosis and in 30-40% of cases with disease progression. Locoregional spread through the peritoneum is considered stage IVc and is associated with a poor prognosis. The development of a regional therapeutic strategy based on cytoreductive surgery, and hyperthermic intra-abdominal chemotherapy has significantly altered the course of the disease.
View Article and Find Full Text PDFPost-exercise management of exertional hyperthermia in dogs participating in dog sport (canicross) events in the UK.
J Therm Biol
April 2024
Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
Article Synopsis
- Exercise is a major cause of heat-related illness (HRI) in dogs, responsible for 74% of cases treated in the UK; there is limited research on effective cooling methods for affected dogs.
- The study monitored temperature changes in dogs after canicross events, evaluating various cooling practices and ambient conditions, finding that many dogs still increased in temperature shortly after exercise.
- Results suggest that cold-water immersion effectively cools hyperthermic dogs, emphasizing the importance of cooling dogs before transportation to prevent further temperature increases.
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