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Chemical upcycling of poly(bisphenol A carbonate) via sequential diamino-/methanolysis: A phosgeneless one-pot route to dimethyl dicarbamate esters.
J Hazard Mater
November 2024
Università degli Studi "Aldo Moro" di Bari, Dipartimento di Chimica, Campus Universitario, Via E. Orabona, 4, 70126 Bari, Italy; Centro Interdipartimentale di Ricerca su Metodologie e Tecnologie Ambientali (METEA), via Celso Ulpiani 27, 70126 Bari, Italy. Electronic address:
Waste poly(bisphenol A carbonate) (PC) is a potential source of harmful bisphenol A (BPA). In this study a new approach aiming to chemically valorize hazardous PC wastes is described. A one-pot process has been developed that allows to recover BPA from PC used as "phosgene equivalent" for the synthesis of dimethyl dicarbamates MeOCNH-R-NHCOMe.
View Article and Find Full Text PDFTailored BODIPY-based fluorogenic probes for phosgene detection: a comparative evaluation of recognition sites.
J Mater Chem B
December 2024
Department of Photonics, Faculty of Science, Izmir Institute of Technology, Turkiye.
We constructed two novel boron-dipyrromethene (BODIPY)-based fluorescent probes, BOPD and BOBA, each equipped with the phosgene specific recognition units -phenylenediamine (OPD) and -aminobenzylamine (OBA) at the 2-position of the BODIPY core. BOPD and BOBA represent rare examples of BODIPY-based probes that operate by modulating an intramolecular charge transfer process (ICT), as validated by computational studies. We systematically compared the analytic performance of those recognition units while focusing on selectivity, fluorescence turn-on ratios and response times.
View Article and Find Full Text PDFChloropicrin induced ocular injury: Biomarkers, potential mechanisms, and treatments.
Toxicol Lett
May 2024
Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA. Electronic address:
Article Synopsis
- Ocular tissue, particularly the cornea, is highly sensitive to chemicals, and the increasing use of chloropicrin (CP) as a pesticide raises risks for both intentional and accidental exposure.
- Exposure to CP leads to immediate damage to the eyes, respiratory system, and skin, but there is limited understanding of how it causes this toxicity or how to effectively treat it.
- The review covers recent research on CP's toxicity mechanisms, potential therapeutic strategies, challenges in studying chemical injuries, and technologies that could help identify medical countermeasures for ocular damage from chemical agents.
Galectin-3 inhibition ameliorates alveolar epithelial cell pyroptosis in phosgene-induced acute lung injury.
Int Immunopharmacol
May 2024
Center of Emergency and Critical Medicine in Jinshan Hospital of Fudan University, Shanghai 201508, China; Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai 201508, China; Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China. Electronic address:
Article Synopsis
- Phosgene, a toxic gas, can lead to serious lung injuries in cases of accidental exposure, and the biological mechanisms behind this injury are not well understood.
- Recent research using single-cell RNA sequencing identified that the protein Galectin-3 (Gal3) was present at significantly higher levels in the lungs of mice affected by phosgene-induced acute lung injury (P-ALI).
- Inhibiting Gal3 and removing specific immune cells (alveolar macrophages) reduced lung cell death and damage in experimental models, suggesting targeting Gal3 could improve treatment strategies for P-ALI.
The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives.
Chem Biol Interact
May 2024
Ecole de Chimie Polymère et Matériaux ECPM, Université de Strasbourg, ICPEES UMR CNRS 7515, 25 rue Becquerel, F-67087, Strasbourg, France; OPGS Pharmaceuticals, Paris BioTech Santé, 24 rue du Faubourg Saint-Jacques, F-75014, Paris, France. Electronic address:
Article Synopsis
- * These nerve agents are highly lethal, targeting the nervous system by blocking an enzyme (AChE) that helps with neurotransmission, leading to severe health issues or death if not treated quickly.
- * Research is focusing on developing better antidotes, such as modified reactivators that can cross the blood-brain barrier, to improve treatment for victims exposed to these toxic agents.
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