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Previous studies have suggested that systemic viral infections may increase risks of dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections is unknown. Determining this is important for anticipating the potential future incidence of dementia.

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In the context of the Sustainable Development Goals (SDGs), which strive to ensure comprehensive access to fundamental water, sanitation, and hygiene (WASH) services, it is extremely imperative to prioritize communities in need and still disadvantaged. Moreover, tackling the worldwide sanitation crisis entails advancing the development of productive and sustainable sanitation systems and infrastructure. Sanitation planning is a multidimensional exercise encompassing multiple dimensions, stakeholders, and strategies, typically with conflicting objectives.

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The Metropolitan Area of São Paulo (MASP) in southern Brazil is impacted by high ozone levels posing significant threats to its urban forests and the Atlantic Forest remnants. These green areas, covering 540 km and constituting 30% of MASP's territory, necessitate an urgent assessment of air pollution impacts on their flora. Our study investigates the effects of atmospheric pollution on the morphoanatomical and physiological responses of four native tree species (Alchornea sidifolia, Casearia sylvestris, Guarea macrophylla, and Machaerium nyctitans) across two Atlantic Forest remnants in MASP.

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Symmetry is integral for the balance and function of the craniofacial complex and making precise diagnosis of asymmetric craniofacial structures is crucial for treatment planning. This study focuses on maxillomandibular asymmetry, examining its impact on condylar resorption and trabecular bone morphology changes following orthognathic surgery. Cone-beam computed tomography (CBCT) scans of patients with and without asymmetry were analyzed pre- and post-surgery.

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Efflux transporters in drug disposition during pregnancy.

Drug Metab Dispos

January 2025

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

Evidence-based dose selection of drugs in pregnant women has been lacking because of challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are administered off-label during pregnancy based on data obtained from nonpregnant women. During pregnancy, drug transporters play an important role in drug disposition along with known gestational age-dependent changes in physiology and drug-metabolizing enzymes.

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