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Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus.
Vaccine
April 2024
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. Electronic address:
Background: The introduction of varicella vaccines into routine pediatric immunization programs has led to a considerable reduction in varicella incidence. However, there have been reports of varicella, herpes zoster, and meningitis caused by the vaccine strain of varicella-zoster virus (VZV), raising concerns. Establishing the relationship between the wild-type and vaccine strains in VZV infections among previously vaccinated individuals is crucial.
View Article and Find Full Text PDFPosition statement on infection screening, prophylaxis, and vaccination of pediatric patients with rheumatic diseases and immunosuppressive therapies, part 3: precautions in situations of surgery, fever, and opportunistic infections.
Eur J Pediatr
February 2024
Department of Pediatrics, Infectious and Tropical Diseases, Hospital Universitario La Paz, La Paz Research Institute (IdiPaz), Translational Research Network of Pediatric Infectious Diseases (RITIP), CIBERINFEC ISCIII, Madrid, Spain.
The objective of this study is to provide practical recommendations on the management of pediatric patients with immune-mediated rheumatic diseases receiving immunosuppressive therapies. The recommendations specifically address the cases of surgery, fever, and opportunistic infections (varicella, herpes-zoster, tuberculosis, invasive fungal disease). A qualitative approach was applied.
View Article and Find Full Text PDFClinical and Laboratory Diagnosis of Exanthems Among Japanese Children Younger Than 6 Years Old in the Post-Measles-Rubella Vaccine Era.
Pediatr Infect Dis J
February 2024
Division of Infectious Diseases, Department of Medical Subspecialties.
Article Synopsis
- Exanthems are a frequent reason for pediatric emergency visits, particularly in children under 6, but there’s limited data post-vaccination for measles and rubella.
- A study in Japan from August 2019 to March 2020 classified the causes of exanthems in young children, using both clinical diagnosis and PCR tests for specific pathogens.
- Results showed that 54% of diagnosed cases were noninfectious or infectious diseases, with notable pathogens identified through PCR, making viral infections the most common underlying causes.
Surveying a Sample of the Spanish Ophthalmologic Community about Vaccination against Herpes Zoster.
Vaccines (Basel)
May 2023
Hospital Regional Universitario de Málaga, Plaza del Hospital Civil, S/N, 29009 Malaga, Spain.
There are currently two authorized vaccines against herpes zoster (HZ) that have been shown to be safe and effective in its prevention: Zostavax, a zoster vaccine live (ZVL), and Shingrix, a recombinant zoster Vaccine (RZV). Because ophthalmologists work with vision-threatening complications of zoster, such as herpes zoster ophthalmicus (HZO), they are in a good position to advocate for vaccination. Our aim was to determine the current knowledge among Spanish ophthalmologists about the effectiveness of the available vaccines against HZ.
View Article and Find Full Text PDFPredictors of herpes zoster severity and immune responses according to pain trajectories: A community-based prospective cohort study.
J Dermatol
August 2023
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
The authors aimed to identify determinants of the clinical course of herpes zoster and immunological responses, focusing on pain trajectories. This prospective community-based cohort study involved the analysis of responses to a valid pain survey provided by 375 patients diagnosed with herpes zoster based on clinical symptoms and virus identification by polymerase chain reaction. The authors analyzed most patients for humoral/cell-mediated immune response against varicella-zoster virus at the onset and 3 months post-onset.
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