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Prevalence of ABH(O) Blood Group Secretors Among Indigenous Population of Shillong: A Cross-Sectional Study.
Cureus
November 2024
Forensic Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Article Synopsis
- ABH antigens on red blood cells determine blood types (A, B, AB, O) and are also present in various body fluids; individuals with these antigens in their fluids are known as secretors.
- A study in Shillong, India, assessed salivary secretor status in 250 healthy adults, revealing a 57.2% prevalence, with notable trends linked to age, sex, tribe, and blood groups.
- Findings highlight the forensic potential of saliva in identifying blood groups, which can assist in legal matters related to paternity, immigration, and disaster victim identification, as it can be more readily available than blood samples.
Role of antihypertensive medicines in prostate cancer: a systematic review.
BMC Cancer
April 2024
Pharmacy Department, General Hospital Aboh, Aboh, Delta State, Nigeria.
Background: Hypertension is associated with the risk of prostate cancer (PCa) and its progression, however, it remains unclear whether antihypertensive medicines alter PCa risk or prognosis. This systematic review evaluated the role of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors in the risk and prognosis of PCa. This review was performed in line with PRISMA 2020 guidelines.
View Article and Find Full Text PDFGalectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain.
Mol Cell Proteomics
May 2024
Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
Although immune tolerance evolved to reduce reactivity with self, it creates a gap in the adaptive immune response against microbes that decorate themselves in self-like antigens. This is particularly apparent with carbohydrate-based blood group antigens, wherein microbes can envelope themselves in blood group structures similar to human cells. In this study, we demonstrate that the innate immune lectin, galectin-4 (Gal-4), exhibits strain-specific binding and killing behavior towards microbes that display blood group-like antigens.
View Article and Find Full Text PDFFUT1 variants responsible for Bombay or para-Bombay phenotypes in a database.
Sci Rep
October 2023
Department of Forensic Medicine, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Rare individuals with Bombay and para-Bombay phenotypes lack or have weak expression of the ABO(H) antigens on surface of red blood cells due to no or very weak H-type α(1,2)fucosyltransferase activity encoded by FUT1. These phenotypes are clinically important because subjects with these phenotypes can only accept transfusions of autologous blood or blood from subjects with the same phenotypes due to the anti-H antibody. To survey FUT1 alleles involved in Bombay and para-Bombay phenotypes, the effect of 22 uncharacterized nonsynonymous SNPs in the Erythrogene database on the α(1,2)fucosyltransferase activity were examined by transient expression studies and in silico analysis using four different online software tools.
View Article and Find Full Text PDFMaternal and Infant Histo-Blood Group Antigen (HBGA) Profiles and Their Influence on Oral Rotavirus Vaccine (Rotarix) Immunogenicity among Infants in Zambia.
Vaccines (Basel)
July 2023
Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia, Lusaka P.O. Box 34681, Zambia.
Article Synopsis
- Live-attenuated oral rotavirus vaccines like ROTARIX have reduced diarrhoea and infant mortality but show reduced effectiveness in low-income countries.
- A study in Zambia with 135 mother-infant pairs assessed the impact of maternal and infant histo-blood group antigen (HBGA) profiles on the vaccine's effectiveness, focusing on seroconversion and IgA antibody levels.
- Results indicated that while early infant HBGA profiles did not significantly affect vaccine responses, infant HBGA profiles were linked to increased immunogenicity at 12 months, highlighting the need for further research to improve vaccine efficacy for young children.
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