Fifteen premature babies developed systemic candidiasis during the administration of intravenous hyperalimentation in the Beilinson Neonatal Intensive Care Unit. Candida albicans was found in the blood cultures of all the babies and in the urine cultures of 66.7% of them. Repeated funduscopic examinations revealed no evidence of septic embolization in the retinal or choroidal circulation. It should be noted that acute retinopathy of prematurity (ROP) grade 2 or 3 was found in all the babies.
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- AMP-17, an antimicrobial peptide, has shown promising antifungal effects and can enhance the effectiveness of fluconazole, a common antifungal drug, in treating systemic candidiasis.
- In tests on infected larvae and mice, AMP-17 significantly improved survival rates, reduced fungal loads, and minimized inflammation, suggesting it could be a novel treatment option for candidiasis, especially when used alongside fluconazole.
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