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Hijacking of plasminogen by dengue virus: The kringle-4 and -5 domains of plasminogen binds synergistically to the domain I of envelope protein.
Protein Sci
February 2025
Department of Biological Sciences, National University of Singapore, Singapore.
Dengue fever is a serious health issue, particularly in tropical countries like Singapore. We have previously found that dengue virus (DENV) recruits human plasmin in blood meal to enhance the permeability of the mosquito midgut for infection. Here, using biolayer interferometry, we found that neither kringle-4 nor kringle-5 plasmin domains alone binds well to dengue virus.
View Article and Find Full Text PDFAll-round enhancement induced by oxophilic single Ru and W atoms for alkaline hydrogen oxidation of tiny Pt nanoparticles.
Nat Commun
January 2025
Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, China.
Anion exchange membrane fuel cells (AEMFCs) are one of the ideal energy conversion devices. However, platinum (Pt), as the benchmark catalyst for the hydrogen oxidation reaction (HOR) of AEMFCs anodes, still faces issues of insufficient performance and susceptibility to CO poisoning. Here, we report the Joule heating-assisted synthesis of a small sized RuPt single-atom alloy catalyst loaded on nitrogen-doped carbon modified with single W atoms (s-RuPt@W/NC), in which the near-range single Ru atoms on the RuPt nanoparticles and the long-range single W atoms on the support simultaneously modulate the electronic structure of the active Pt-site, enhancing alkaline HOR performance of s-RuPt@W/NC.
View Article and Find Full Text PDFElectron-phonon coupling and coherent energy superposition induce spin-sensitive orbital degeneracy for enhanced acidic water oxidation.
Nat Commun
January 2025
Institute of Biomedical Engineering, College of Life Sciences, Qingdao University, Qingdao, China.
The development of acid-stable water oxidation electrocatalysts is crucial for high-performance energy conversion devices. Different from traditional nanostructuring, here we employ an innovative microwave-mediated electron-phonon coupling technique to assemble specific Ru atomic patterns (instead of random Ru-particle depositions) on MnCrO surfaces (Ru-MnCrO) in RuCl solution because hydrated Ru-ion complexes can be uniformly activated to replace some Mn sites at nearby Cr-dopants through microwave-triggered energy coherent superposition with molecular rotations and collisions. This selective rearrangement in Ru-MnCrO with particular spin-differentiated polarizations can induce localized spin domain inversion from reversed to parallel direction, which makes Ru-MnCrO demonstrate a high current density of 1.
View Article and Find Full Text PDFRigorous Analysis of Multimodal HDX-MS Spectra.
J Am Soc Mass Spectrom
January 2025
Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.
An inherent strength of hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) is its ability to detect the presence of multiple conformational states of a protein, which often manifest as multimodal isotopic envelopes. However, the statistical considerations for accurate analysis of multimodal spectra have yet to be established. Here we outline an unrestrained binomial distribution fitting approach with the corresponding statistical tests to accurately detect and, when possible, deconvolute isotopic distributions that contain multiple subpopulations.
View Article and Find Full Text PDFA Structural Model of Truncated Gaussia princeps Luciferase Elucidating the Crucial Catalytic Function of No.76 Arginine towards Coelenterazine Oxidation.
PLoS Comput Biol
January 2025
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, People's Republic of China.
Gaussia Luciferase (GLuc) is a renowned reporter protein that can catalyze the oxidation of coelenterazine (CTZ) and emit a bright light signal. GLuc comprises two consecutive repeats that form the enzyme body and a central putative catalytic cavity. However, deleting the C-terminal repeat only limited reduces the activity (over 30% residual luminescence intensity detectable), despite being a key part of the cavity.
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