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Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique.
AIDS Res Ther
January 2025
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutations in patients on DTG in Mozambique through a retrospective cohort study in seven DREAM centers. Data from 29,601 patients (98.
View Article and Find Full Text PDFThe antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.
BMC Oral Health
January 2025
Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
Background: To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material.
Methods: Conventional GIC was incorporated with different concentrations of AgNW and silver nanoparticles (AgNP). Multi-species biofilms of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus fermentum, and Lactobacillus rhamnosus were cultured for 72 h on GIC specimens.
High sensitivity flexible strain sensor for motion monitoring based on MWCNT@MXene and silicone rubber.
Sci Rep
January 2025
Mechanical and Industrial Engineering Department, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Research on flexible strain sensors has grown rapidly and is widely applied in the fields of soft robotics, body motion detection, wearable sensors, health monitoring, and sports. In this study, MXene was successfully synthesized in powder form and combined with multi-walled carbon nanotube (MWCNT) to develop MWCNT@MXene conductive network-based flexible strain sensors with silicone rubber (SR) substrate. Combining MWCNTs with MXene as a conductive material has been shown to significantly improve the sensor performance, due to MXene's high conductivity properties that strengthen the MWCNT conductive pathway, increase sensitivity, and improve sensor stability.
View Article and Find Full Text PDFA comparative analysis of collagen based dressings and polysaccharide microspheres for hemostasis management in hepatic stab wounds.
Sci Rep
January 2025
General and Digestive Unit, Central Hospital of Defense, Spanish-Ministry of Defense, Glorieta del Ejército, 1, 28047, Madrid, Spain.
This study aims to evaluate two of the most commonly used products, the collagen-based patch (Hemopatch) and the micropolysaccharide microspheres powder (Perclot), in the context of stab liver injury in pigs. The objectives of this study were to assess blood loss at various time intervals up to 24 h, survival rates, and mean arterial pressure. The research involved 18 Large-White swine.
View Article and Find Full Text PDFIdentifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry.
NPJ Vaccines
January 2025
Department of Biochemistry, University of Oxford, OX1 3QU, Oxford, UK.
The rapid development and worldwide distribution of COVID-19 vaccines is a remarkable achievement of biomedical research and logistical implementation. However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. In this context, matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS) is globally available for fast and accurate analysis of bacteria in patient samples, offering a potentially accessible solution to identify SF vaccines.
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